Do malaria parasites manipulate mosquitoes?

Do malaria parasites manipulate mosquitoes?
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DOI:
10.1016/j.pt.2012.08.004
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发表时间:
2012-11
影响因子:
9.6
通讯作者:
Thomas MB
Thomas MB
中科院分区:
医学1区
文献类型:
--
作者:
Cator LJ;Lynch PA;Read AF;Thomas MB

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疟疾寄生虫被认为可以改变蚊子媒介的行为,从而增加传播的可能性。一些经验证据支持这一假设,但在大多数流行病学模型中,操纵的作用被忽视,感染和未感染的女性之间的行为差异没有被考虑在控制措施的制定或实施。我们认为,这种脱节的存在,因为行为改变和实际传播之间的联系,在外地尚未得到充分证明或量化。我们回顾和讨论了目前的证据操纵,探讨其对疟疾传播的潜在意义,并建议如何将这一假设从理论推向疟疾控制的潜在应用。
Malaria parasites have been suggested to alter the behavior of mosquito vectors to increase the likelihood of transmission. Some empirical evidence supports this hypothesis, yet the role of manipulation is ignored in most epidemiological models, and behavioral differences between infected and uninfected females are not considered in the development or implementation of control measures. We suggest that this disconnect exists because the link between behavioral alteration and actual transmission in the field has yet to be fully demonstrated or quantified. We review and discuss the current evidence for manipulation, explore its potential significance for malaria transmission and suggest ways to move this hypothesis forward from theory to potential application in malaria control.
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