Factors influencing frontal cortex development and recovery from early frontal injury.
Factors influencing frontal cortex development and recovery from early frontal injury.
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DOI：
10.3109/17518420903087715
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发表时间：
2009
影响因子：
1.3
通讯作者：
Kolb B
中科院分区：
文献类型：
--
作者：
Halliwell C;Comeau W;Gibb R;Frost DO;Kolb B
新皮层的发育不仅仅是遗传蓝图的简单展开，而是遗传和环境事件的复杂舞蹈，这些事件相互作用，使大脑适应特定的环境背景。虽然大多数皮层区域在发育过程中和以后的生活中对各种经验因素都很敏感，但前额叶皮层似乎对围产期经历异常敏感，相对于其他新皮层区域，对许多成年经历相对免疫。检验经验依赖性前额叶发育的一种方法是进行经验扰动与神经元形态学相关的研究。这项研究的回顾表明，产前和产后因素对前额发育和行为都有重要影响。这些因素包括精神活性药物（包括非法药物和处方药）、压力、性腺激素以及感觉和运动刺激。第二种研究方法是研究围产期前额损伤对剩余大脑地幔和相关行为的发展的影响，以及损伤后康复计划对解剖和行为措施的影响。前额叶损伤以发育阶段依赖的方式改变大脑发育，围产期损伤的有害影响远大于婴儿期后期的类似损伤。然而，围产期损伤的结果可以通过康复来改变，其中许多因素被证明会影响正常大脑中的前额叶发育。
Neocortical development represents more than a simple unfolding of a genetic blueprint but rather represents a complex dance of genetic and environmental events that interact to adapt the brain to fit a particular environmental context. Although most cortical regions are sensitive to a wide range of experiential factors during development and later in life, the prefrontal cortex appears to be unusually sensitive to perinatal experiences and relatively immune to many adulthood experiences relative to other neocortical regions. One way to examine experience-dependent prefrontal development is to conduct studies in which experiential perturbations are related neuronal morphology. This review of the research reveals both pre- and post-natal factors have important effects on prefrontal development and behaviour. Such factors include psychoactive drugs, including both illicit drugs and prescription drugs, stress, gonadal hormones and sensory and motor stimulation. A second method of study is to examine both the effects of perinatal prefrontal injury on the development of the remaining cerebral mantle and correlated behaviours as well as the effects of post-injury rehabilitation programmes on the anatomical and behavioural measures. Prefrontal injury alters cerebral development in a developmental-stage dependent manner with perinatal injuries having far more deleterious effects than similar injuries later in infancy. The outcome of perinatal injuries can be modified, however, by rehabilitation with many of the factors shown to influence prefrontal development in the otherwise normal brain.
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影响因子：
3.4
作者：
Heijtz, RD;Kolb, B;Forssberg, H
通讯作者：
Forssberg, H
影响因子：
2.9
作者：
KOLB, B;GIBB, R;VANDERKOOY, D
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VANDERKOOY, D
影响因子：
2.9
作者：
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影响因子：
4.7
作者：
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Kolb, Bryan
影响因子：
2.9
作者：
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通讯作者：
GALKIN, TW