Actual concepts in rhinosinusitis: a review of clinical presentations, inflammatory pathways, cytokine profiles, remodeling, and management.
Actual concepts in rhinosinusitis: a review of clinical presentations, inflammatory pathways, cytokine profiles, remodeling, and management.
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鼻孔炎的实际概念：临床表现，炎症途径，细胞因子谱，重塑和管理的综述。
DOI：
10.1007/s11882-011-0180-0
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发表时间：
2011-04
影响因子：
5.5
通讯作者：
Bertrand B
中科院分区：
文献类型：
--
作者：
Eloy P;Poirrier AL;De Dorlodot C;Van Zele T;Watelet JB;Bertrand B
鼻鼻窦炎（RS）是一种异质性疾病。这是一个严重且日益严重的健康问题，影响着西方国家约15%的人口。它对患者与健康相关的生活质量和日常功能产生重大影响，并由于直接和间接成本而给社会和卫生保健系统带来巨大的经济负担。此外，RS的发病机制尚不清楚，其病因和病理生理机制尚不清楚。在过去的十年中，许多论文的发表改变了我们对RS的认识。RS通常根据症状持续时间分为急性和慢性RS。在急性呼吸道合并症中，由病毒感染引起的炎症反应是大多数不复杂的轻度至中度病例的特征。因此，这些病例的一线治疗是鼻内类固醇而不是抗生素。在严重和复杂的情况下，抗生素联合局部类固醇仍然是治疗的选择。另一方面，慢性RS实际上被细分为两种不同的实体（慢性鼻窦炎伴息肉和不伴息肉），因为越来越多的证据表明这些实体具有特定的炎症途径和细胞因子谱。作者回顾了最近关于临床表现、细胞因子谱、组织重塑和各种形式RS治疗方式的数据。
Rhinosinusitis (RS) is a heterogeneous group of diseases. It is a significant and increasing health problem that affects about 15% of the population in Western countries. It has a substantial impact on patients’ health-related quality of life and daily functioning and represents a huge financial burden to society and the health care system as a result of the direct and indirect costs. In addition, RS is not well-understood, and little is known about the etiology and pathophysiology. In the past decade, many papers have been published that have changed our understanding of RS. RS is commonly classified into acute and chronic RS based on symptom duration. In acute RS, an inflammatory reaction initiated by a viral infection characterizes most uncomplicated, mild to moderate cases. Therefore, the first line of treatment for these cases are intranasal steroids and not antibiotics. In severe and complicated cases, antibiotics combined with topical steroids remain the treatment of choice. On the other hand, chronic RS is actually subdivided into two distinct entities (chronic rhinosinusitis with and without polyps), as growing evidence indicates that these entities have specific inflammatory pathways and cytokine profiles. The authors review recent data regarding the clinical presentations, cytokine profiles, tissue remodeling, and modalities of treatment for each form of RS.
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影响因子：
14.2
作者：
Bachert, C;Wagenmann, M;Rudack, C
通讯作者：
Rudack, C
影响因子：
11.5
作者：
Campbell, A;Michel, FB;Bousquet, J
通讯作者：
Bousquet, J
影响因子：
14.2
作者：
Bachert, C;Gevaert, P;van Cauwenberge, P
通讯作者：
van Cauwenberge, P
影响因子：
3.4
作者：
Bernstein, JM;Lebowitz, RA;Jacobs, JB
通讯作者：
Jacobs, JB
影响因子：
1.4
作者：
Chao, Siew-Shuen;Graham, Scott M.;Hussain, Iftikhar
通讯作者：
Hussain, Iftikhar