Clinical and genetic predictors of weight gain in patients diagnosed with breast cancer.
Clinical and genetic predictors of weight gain in patients diagnosed with breast cancer.
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DOI：
10.1038/bjc.2013.441
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发表时间：
2013-08-20
影响因子：
8.8
通讯作者：
Kaklamani, V. G.
中科院分区：
文献类型：
--
作者：
Reddy, S. M.;Sadim, M.;Li, J.;Yi, N.;Agarwal, S.;Mantzoros, C. S.;Kaklamani, V. G.
乳腺癌患者诊断后体重增加与癌症复发和死亡率增加有关。我们的研究旨在确定这种体重增加的风险因素，并创建一个预测模型，以确定针对性干预的高风险人群。对来自西北大学的459名乳腺癌患者进行了病历回顾。Lurie癌症中心获得诊断后18个月内的体重和体重指数（BMI）。我们还记录了肿瘤特征、人口统计学、临床因素和治疗方案。对血液样本进行脂肪量和肥胖相关蛋白（FTO）以及脂联素途径基因（ADIPOQ和ADIPOR 1）的14个单核苷酸多态性（SNP）基因分型。总体而言，从诊断到18个月，56%的患者BMI增加>0.5 kg m-2，平均BMI和体重增加分别为1.9 kg m-2和5.1 kg。我们的最佳预测模型是一个主要基于SNP的模型，包括研究的所有14个FTO和脂联素途径SNP、它们的上位相互作用、诊断时的年龄和BMI，18个月体重增加的受试者工作特征曲线下面积为0.85。我们创建了一个强大的风险预测模型，可以识别体重增加风险高的乳腺癌患者。
Post-diagnosis weight gain in breast cancer patients has been associated with increased cancer recurrence and mortality. Our study was designed to identify risk factors for this weight gain and create a predictive model to identify a high-risk population for targeted interventions. Chart review was conducted on 459 breast cancer patients from Northwestern Robert H. Lurie Cancer Centre to obtain weights and body mass indices (BMIs) over an 18-month period from diagnosis. We also recorded tumour characteristics, demographics, clinical factors, and treatment regimens. Blood samples were genotyped for 14 single-nucleotide polymorphisms (SNPs) in fat mass and obesity-associated protein (FTO) and adiponectin pathway genes (ADIPOQ and ADIPOR1). In all, 56% of patients had >0.5 kg m–2 increase in BMI from diagnosis to 18 months, with average BMI and weight gain of 1.9 kg m–2 and 5.1 kg, respectively. Our best predictive model was a primarily SNP-based model incorporating all 14 FTO and adiponectin pathway SNPs studied, their epistatic interactions, and age and BMI at diagnosis, with area under receiver operating characteristic curve of 0.85 for 18-month weight gain. We created a powerful risk prediction model that can identify breast cancer patients at high risk for weight gain.
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DOI：
10.1016/j.jada.2011.10.022
发表时间：
2012-04-01
影响因子：
4.8
作者：
Campbell, Kristin L.;Van Patten, Cheri L.;McKenzie, Donald C.
通讯作者：
McKenzie, Donald C.
影响因子：
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作者：
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影响因子：
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作者：
Goodwin, PJ;Ennis, M;Redwood, S
通讯作者：
Redwood, S
影响因子：
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作者：
Campbell, K. L.;Lane, K.;McKenzie, D. C.
通讯作者：
McKenzie, D. C.