Effect of probiotic Bifidobacterium bifidum G9-1 on the relationship between gut microbiota profile and stress sensitivity in maternally separated rats.
Effect of probiotic Bifidobacterium bifidum G9-1 on the relationship between gut microbiota profile and stress sensitivity in maternally separated rats.
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DOI：
10.1038/s41598-018-30943-3
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发表时间：
2018-08-17
影响因子：
4.6
通讯作者：
Miwa H
中科院分区：
文献类型：
--
作者：
Fukui H;Oshima T;Tanaka Y;Oikawa Y;Makizaki Y;Ohno H;Tomita T;Watari J;Miwa H
虽然肠道菌群和早期生活事件可能与肠易激综合征（IBS）的发展有关，但这些因素如何在IBS的病理生理中相互作用仍不清楚。本研究以母性分离（MS）大鼠作为IBS模型，研究了肠道菌群、应激敏感性和肠通透性之间的相互关系，并研究了益生菌两歧双歧杆菌G9-1 （BBG9-1）在这些相互关系中的作用。与对照组相比，出生后第20天，MS大鼠出现高皮质酮血症，肠道通透性增强，肠道微生物群结构改变。在MS大鼠中，BBG9-1可以预防所有这些变化。尽管在出生后第56天，MS大鼠的肠道微生物群和基础血清皮质酮水平与对照大鼠没有差异，但MS大鼠在血清皮质酮水平和粪便频率方面表现出对约束应激的超敏感。然而，在用BBG9-1治疗的MS大鼠中未观察到这种超敏反应。这些发现表明，多发性硬化症启动了肠道菌群改变和应激过敏之间的联系，而益生菌BBG9-1的治疗可以防止这一过程的触发。
Although gut microbiota and early life events are likely involved in the development of irritable bowel syndrome (IBS), it remains unclear how these factors interact in the pathophysiology of IBS. In the present study, using rats subjected to maternal separation (MS) as a model of IBS, we investigated interrelationships among gut microbiota, stress susceptibility and intestinal permeability, and examined the effect of the probiotic Bifidobacterium bifidum G9-1 (BBG9-1) on those interrelationships. When compared with the controls at postnatal day 20, MS rats showed hypercorticosteronemia, enhanced intestinal permeability and changes in gut microbiota structure. All of these changes in MS rats were prevented by treatment with BBG9-1. Although the gut microbiota profile and basal serum corticosterone level did not differ between MS and control rats at postnatal day 56, MS rats showed hypersensitivity to restraint stress in terms of serum corticosterone level and fecal frequency. However, such hypersensitivity was not observed in MS rats treated with BBG9-1. These findings suggest that MS initiates the link between gut microbiota alteration and hypersensitivity to stress and that the triggering of this process can be prevented by the treatment with the probiotic BBG9-1.
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影响因子：
15.5
作者：
Fadrosh DW;Ma B;Gajer P;Sengamalay N;Ott S;Brotman RM;Ravel J
通讯作者：
Ravel J
DOI：
10.1111/1440-1681.12792
发表时间：
2017-10-01
影响因子：
2.9
作者：
Kato, Shinichi;Hamouda, Nahla;Shimakawa, Masaki
通讯作者：
Shimakawa, Masaki
影响因子：
24.5
作者：
Jalanka-Tuovinen, Jonna;Salojarvi, Jarkko;de Vos, Willem M.
通讯作者：
de Vos, Willem M.
影响因子：
3.7
作者：
Barouei J;Moussavi M;Hodgson DM
通讯作者：
Hodgson DM
影响因子：
3.7
作者：
Crost EH;Tailford LE;Le Gall G;Fons M;Henrissat B;Juge N
通讯作者：
Juge N