Investigating the Neural Basis of Theta Burst Stimulation to Premotor Cortex on Emotional Vocalization Perception: A Combined TMS-fMRI Study.
Investigating the Neural Basis of Theta Burst Stimulation to Premotor Cortex on Emotional Vocalization Perception: A Combined TMS-fMRI Study.
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DOI：
10.3389/fnhum.2018.00150
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发表时间：
2018
影响因子：
2.9
通讯作者：
Scott SK
中科院分区：
文献类型：
--
作者：
Agnew ZK;Banissy MJ;McGettigan C;Walsh V;Scott SK
之前的研究已经确定了前运动皮质在听觉情感发声处理中的作用。抑制性连续theta爆发经颅磁刺激（cTBS）施加到右前运动皮层选择性地增加反应时间，以一个相同的不同的任务，这意味着因果关系的作用，右腹侧前运动皮层（PMV）在处理情绪的声音。然而，很少有人知道的功能网络，PMV有助于整个皮质半球。根据这些数据，本研究旨在研究cTBS如何以及在大脑中何处影响听觉情感发声过程中的活动。使用功能性神经影像学，我们报告说，抑制cTBS适用于右前运动皮层（相比，顶点控制网站）的结果在三个不同的响应配置文件：以下刺激PMV，广泛的额顶叶皮质，包括一个网站接近目标网站，和海马旁回显示活动增加，而反向响应配置文件是明显的一组中线结构和右IFG。第三个响应曲线出现在左侧缘上回，其中两个刺激部位的刺激后活动更大。最后，虽然以前的研究表明，条件特定的行为影响后，cTBS运动前皮质，我们没有发现条件特定的神经变化BOLD反应。这些数据表明，在广泛的神经网络cTBS和活动之间的复杂关系，并讨论有关的情感处理和cTBS的神经基础。
Previous studies have established a role for premotor cortex in the processing of auditory emotional vocalizations. Inhibitory continuous theta burst transcranial magnetic stimulation (cTBS) applied to right premotor cortex selectively increases the reaction time to a same-different task, implying a causal role for right ventral premotor cortex (PMv) in the processing of emotional sounds. However, little is known about the functional networks to which PMv contribute across the cortical hemispheres. In light of these data, the present study aimed to investigate how and where in the brain cTBS affects activity during the processing of auditory emotional vocalizations. Using functional neuroimaging, we report that inhibitory cTBS applied to the right premotor cortex (compared to vertex control site) results in three distinct response profiles: following stimulation of PMv, widespread frontoparietal cortices, including a site close to the target site, and parahippocampal gyrus displayed an increase in activity, whereas the reverse response profile was apparent in a set of midline structures and right IFG. A third response profile was seen in left supramarginal gyrus in which activity was greater post-stimulation at both stimulation sites. Finally, whilst previous studies have shown a condition specific behavioral effect following cTBS to premotor cortex, we did not find a condition specific neural change in BOLD response. These data demonstrate a complex relationship between cTBS and activity in widespread neural networks and are discussed in relation to both emotional processing and the neural basis of cTBS.
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DOI：
10.1093/cercor/bhn181
发表时间：
2009-06
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Gazzola V;Keysers C
通讯作者：
Keysers C
用fMRI绘制TMS的效果：在分布式网络中支持语义控制的皮质募集的调节。
影响因子：
2.6
作者：
Hallam GP;Whitney C;Hymers M;Gouws AD;Jefferies E
通讯作者：
Jefferies E
影响因子：
2.6
作者：
Binney RJ;Ralph MA
通讯作者：
Ralph MA
影响因子：
2.5
作者：
Dancause, Numa;Barbay, Scott;Nudo, Randolph J.
通讯作者：
Nudo, Randolph J.
神经元网络在驱动人类运动皮层可塑性中的作用
影响因子：
3.7
作者：
Hamada, Masashi;Murase, Nagako;Rothwelll, John C.
通讯作者：
Rothwelll, John C.