Biodegradable Nitrogen-Doped Carbon Nanodots for Non-Invasive Photoacoustic Imaging and Photothermal Therapy.
Biodegradable Nitrogen-Doped Carbon Nanodots for Non-Invasive Photoacoustic Imaging and Photothermal Therapy.
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可生物降解的氮含碳纳米纳米原子，用于非侵入性光声成像和光热疗法。
作者：
Lee C;Kwon W;Beack S;Lee D;Park Y;Kim H;Hahn SK;Rhee SW;Kim C
多功能纳米粒子在生物医学领域的应用已经得到了广泛的研究，如成像、治疗和药物递送。特别是，光活性纳米颗粒作为治疗诊断剂受到了极大的关注，因为它们在暴露于激光照射后具有生热能力。然而，光稳定性和安全性问题一直是进一步临床应用的技术障碍。在这里，我们设计了氮（N）掺杂的碳纳米点（N-CND），在近红外区域具有强吸收，高光稳定性和优异的生物降解性。优化的N-CND不仅可以作为一种新的光声（PA）成像剂，而且由于其在特定波长处的强光学吸收，还可以作为体内上级光热治疗（PTT）剂。我们使用N-CND通过局部递送对前哨淋巴结进行体内/离体非侵入性PA成像，并进行PTT进行癌症消融治疗。最后，通过进行全身PA监测和降解试验证实了生物降解和肾清除。
Multifunctional nanoparticles have been widely investigated for biomedical applications, such as imaging, therapy, and drug delivery. Especially, photoactive nanoparticles have received great attention as theranostic agents because of their heat-generating abilities after exposure to laser irradiation. However, photostability and safety issues have been the technical hurdles for further clinical applications. Here, we designed nitrogen (N)-doped carbon nanodots (N-CNDs) that have strong absorption in the near-infrared region, high photostability, and excellent biodegradability. Optimized N-CNDs can be utilized not only as a new photoacoustic (PA) imaging agent but also as a superior photothermal therapy (PTT) agent in vivo because of their strong optical absorption at a specific wavelength. We used N-CNDs to perform in vivo/ex vivo noninvasive PA imaging of sentinel lymph nodes via local delivery and performed PTT for cancer ablation therapy. Finally, biodegradation and renal clearance were confirmed by performing whole-body PA monitoring and a degradation test.
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影响因子：
19
作者：
Chen J;Yang M;Zhang Q;Cho EC;Cobley CM;Kim C;Glaus C;Wang LV;Welch MJ;Xia Y
通讯作者：
Xia Y
影响因子：
4.6
作者：
Bhunia, Susanta Kumar;Saha, Arindam;Maity, Amit Ranjan;Ray, Sekhar C.;Jana, Nikhil R.
通讯作者：
Jana, Nikhil R.
影响因子：
38.3
作者：
通讯作者：
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叶酸共轭二氧化硅修饰的金纳米棒用于 X 射线/CT 成像引导的双模辐射和光热治疗
影响因子：
14
作者：
Huang, Peng;Bao, Le;Cui, Daxiang
通讯作者：
Cui, Daxiang
用于活体小鼠荧光、光声和热治疗诊断的红光碳点
影响因子：
29.4
作者：
Ge, Jiechao;Jia, Qingyan;Wang, Pengfei
通讯作者：
Wang, Pengfei