Virtual memory cells make a major contribution to the response of aged influenza-naïve mice to influenza virus infection.
Virtual memory cells make a major contribution to the response of aged influenza-naïve mice to influenza virus infection.
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DOI：
10.1186/s12979-018-0122-y
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Blackman MA
中科院分区：
文献类型：
--
作者：
Lanzer KG;Cookenham T;Reiley WW;Blackman MA
不同的naïve T细胞库被认为是对新感染的强大反应所必需的。然而，T细胞室老化的一个关键方面是外周naïve T细胞数量和多样性的下降。我们假设naïve T细胞与年龄相关的下降迫使免疫系统使用由先前感染产生的交叉反应记忆T细胞对新的感染做出反应，这些感染主导着衰老的外周T细胞库。在这里，我们证实老年influenza-naïve小鼠对流感病毒原发感染的CD8 T细胞反应主要由来自记忆T细胞池的T细胞主导。这些细胞表现出虚拟记忆细胞的表型特征，而不是真正的记忆细胞。此外，我们发现与年轻小鼠相比，应答CD8 T细胞的库受到限制，并且在单个老年小鼠之间存在显着差异。感染后，这些虚拟记忆CD8 T细胞有效地发育成产生颗粒酶的效应细胞，并以与幼年小鼠naïve CD8 T细胞相当的动力学清除病毒。老年流感初发小鼠对新流感感染的反应主要是由记忆性CD8 T细胞介导的。然而，出乎意料的是，它们具有VM细胞的表型。在对新发流感病毒感染的反应中，VM细胞发育成颗粒酶产生效应细胞和清除病毒，其动力学与年轻的CD8 T细胞相当。本文的在线版本（10.1186/s12979-018-0122-y）包含补充材料，可供授权用户使用。
A diverse repertoire of naïve T cells is thought to be essential for a robust response to new infections. However, a key aspect of aging of the T cell compartment is a decline in numbers and diversity of peripheral naïve T cells. We have hypothesized that the age-related decline in naïve T cells forces the immune system to respond to new infections using cross-reactive memory T cells generated to previous infections that dominate the aged peripheral T cell repertoire. Here we confirm that the CD8 T cell response of aged, influenza-naïve mice to primary infection with influenza virus is dominated by T cells that derive from the memory T cell pool. These cells exhibit the phenotypic characteristics of virtual memory cells rather than true memory cells. Furthermore, we find that the repertoire of responding CD8 T cells is constrained compared with that of young mice, and differs significantly between individual aged mice. After infection, these virtual memory CD8 T cells effectively develop into granzyme-producing effector cells, and clear virus with kinetics comparable to naïve CD8 T cells from young mice. The response of aged, influenza-naive mice to a new influenza infection is mediated largely by memory CD8 T cells. However, unexpectedly, they have the phenotype of VM cells. In response to de novo influenza virus infection, the VM cells develop into granzyme-producing effector cells and clear virus with comparable kinetics to young CD8 T cells. The online version of this article (10.1186/s12979-018-0122-y) contains supplementary material, which is available to authorized users.
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影响因子：
56.9
作者：
Arstila, TP;Casrouge, A;Kourilsky, P
通讯作者：
Kourilsky, P
DOI：
10.1084/jem.20081829
发表时间：
2009-02-16
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Haluszczak C;Akue AD;Hamilton SE;Johnson LD;Pujanauski L;Teodorovic L;Jameson SC;Kedl RM
通讯作者：
Kedl RM
DOI：
10.4049/jimmunol.0900641
发表时间：
2009-09-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Cheung KP;Yang E;Goldrath AW
通讯作者：
Goldrath AW
影响因子：
16.6
作者：
Abolins S;King EC;Lazarou L;Weldon L;Hughes L;Drescher P;Raynes JG;Hafalla JCR;Viney ME;Riley EM
通讯作者：
Riley EM
影响因子：
4.4
作者：
Hadrup, SR;Strindhall, J;Wikby, A
通讯作者：
Wikby, A