Characterizing firefighter's exposure to over 130 SVOCs using silicone wristbands: A pilot study comparing on-duty and off-duty exposures.
Characterizing firefighter's exposure to over 130 SVOCs using silicone wristbands: A pilot study comparing on-duty and off-duty exposures.
复制标题
DOI：
10.1016/j.scitotenv.2022.155237
复制
发表时间：
2022-08-15
影响因子：
9.8
通讯作者：
Stapleton, Heather M.
中科院分区：
文献类型：
--
作者：
Levasseur, Jessica L.;Hoffman, Kate;Herkert, Nicholas J.;Cooper, Ellen;Hay, Duncan;Stapleton, Heather M.
消防员在职业上暴露于一系列危险化学品中，这些暴露与消防员患某些癌症的几率较高有关。然而，需要对消防员的暴露进行更多研究，以充分阐明对健康风险的影响。在一项试点研究中，我们使用硅胶腕带来量化北卡罗来纳州达勒姆的20名消防员在下班和上班时所经历的化学品暴露。通过使用每个消防员的下班腕带代表个人的基线暴露，我们评估了职业相关的暴露（即值班暴露）。我们还调查了值班时应对火灾事件的影响。使用GC-MS/MS和LC-MS/MS目标方法总共定量了134种化学物质。在至少50%的硅胶腕带中检测到71种化学物质，其中包括7种PFAS，据我们所知，以前从未在腕带中报告过。其中，邻苯二甲酸酯的浓度通常最高，其次是溴化阻燃剂（BFR）和有机磷酸酯（OPEs）。测量的全氟辛烷磺酸总体浓度较低，但消防员在执勤和应对火灾时的全氟辛烷磺酸暴露量是下班时的2.5倍。暴露于多环芳烃（PAH），溴化阻燃剂，和一些OPEs的职业相关，与消防员经历0.5至8.5倍，而在值班相比，下班。对火灾做出反应的消防员的PAH暴露也高于那些在值班时没有反应的消防员。在这项试点调查的基础上，对更多的消防员进行的额外研究可能会进一步查明可能导致消防员患癌症风险的暴露源，例如消防员装备或直接来自火灾的暴露源。这项研究证明了使用硅胶腕带量化消防员职业暴露的实用性，以及解开可能特定于火灾事件的暴露与消防员可能经历的其他来源的能力。
Firefighters are occupationally exposed to an array of hazardous chemicals, and these exposures have been linked to the higher rates of some cancer in firefighters. However, additional research that characterizes firefighters’ exposure is needed to fully elucidate the impacts on health risks. In a pilot study, we used silicone wristbands to quantify off-duty and on-duty chemical exposures experienced by 20 firefighters in Durham, North Carolina. By using each firefighter’s off-duty wristband to represent individual baseline exposures, we assessed occupation-related exposures (i.e. on-duty exposures). We also investigated the influence of responding to a fire event while on-duty. In total, 134 chemicals were quantified using both GC-MS/MS and LC-MS/MS targeted methods. Seventy-one chemicals were detected in at least 50% of all silicone wristbands, including 7 PFAS, which to our knowledge, have not been reported on wristbands previously. Of these, phthalates were generally measured at the highest concentrations, followed by brominated flame retardants (BFRs) and organophosphate esters (OPEs). PFAS were measured at lower concentrations overall, but firefighter PFOS exposures while on-duty and responding to fires were 2.5 times higher than off-duty exposures. Exposure to polycyclic aromatic hydrocarbons (PAH), BFRs, and some OPEs were occupationally associated, with firefighters experiencing 0.5 to 8.5 times higher exposure while on-duty as compared to off-duty. PAH exposures were also higher for firefighters who respond to a fire than those who did not while on-duty. Additional research with a larger population of firefighters that builds upon this pilot investigation may further pinpoint exposure sources that may contribute to firefighters’ risk for cancer, such as those from firefighter gear or directly from fires. This research demonstrates the utility of using silicone wristbands to quantify occupational exposure in firefighters and the ability to disentangle exposures that may be specific to fire events as opposed to other sources that firefighters might experience.
登录
查看更多内容
影响因子：
11.4
作者：
Hammel SC;Phillips AL;Hoffman K;Stapleton HM
通讯作者：
Stapleton HM
影响因子：
11.4
作者：
Kassotis CD;Herkert NJ;Hammel SC;Hoffman K;Xia Q;Kullman SW;Sosa JA;Stapleton HM
通讯作者：
Stapleton HM
影响因子：
11.4
作者：
Hammel SC;Hoffman K;Webster TF;Anderson KA;Stapleton HM
通讯作者：
Stapleton HM
燃烧副产品及其健康效应 - 21世纪的燃烧工程和全球健康：问题和挑战。
影响因子：
2.2
作者：
Lomnicki S;Gullett B;Stöger T;Kennedy I;Diaz J;Dugas TR;Varner K;Carlin DJ;Dellinger B;Cormier SA
通讯作者：
Cormier SA
皮肤擦拭巾中邻苯二甲酸盐的测量：估计皮肤吸收的暴露量
影响因子：
11.4
作者：
Gong, Mengyan;Zhang, Yinping;Weschler, Charles J.
通讯作者：
Weschler, Charles J.