In humans, striato-pallido-thalamic projections are largely segregated by their origin in either the striosome-like or matrix-like compartments.
In humans, striato-pallido-thalamic projections are largely segregated by their origin in either the striosome-like or matrix-like compartments.
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DOI：
10.3389/fnins.2023.1178473
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发表时间：
2023
影响因子：
4.3
通讯作者：
Waugh, Jeff L.
中科院分区：
文献类型：
--
作者：
Funk, Adrian T.;Hassan, Asim A. O.;Bruggemann, Norbert;Sharma, Nutan;Breiter, Hans C.;Blood, Anne J.;Waugh, Jeff L.
关键词：
皮质-纹状体-丘脑-皮质（CSTC）环是哺乳动物大脑中的基本组织单位。CSTCs在很大程度上分离但相互作用的网络中处理边缘、联想和感觉运动信息。CTSC环穿过成对的纹状体隔室、纹状体（也称为斑块）和基质、具有不同胚胎起源、皮质/皮质下结构连接、对损伤的易感性以及在行为和疾病中的作用的中等多刺投射神经元的分离池。同样，纹状体多巴胺以相反的方向调节纹状体和基质的活性。通过一个隔室路由CSTCs可能是调节离散功能的解剖学基础。我们使用差分结构连接，通过概率扩散纤维束成像，区分纹状体车厢（纹状体样和矩阵样体素）在活着的人。然后，我们绘制了221名健康成年人的每个纹状体区室，苍白球内（GPi）和20个丘脑核之间的特定区域投影和量化结构连接。我们发现，纹状体起源和基质起源的流线分离内的GPi：纹状体样连接显着更吻，腹，和内侧。纹状体-苍白球-丘脑流线束是从纹状体样和基质样体素中产生的，它们在空间上不同的部分过渡到白色物质中。类似矩阵的流线到达GPi的可能性高出5.7倍，重复了动物轨迹追踪研究。纹状体样连接占主导地位的6个丘脑核（前腹，中央外侧，laterodorpal，外侧后，mediodorsal-medial，内侧膝状体）。丘脑中央核、束旁核、枕前核、枕外侧核、腹侧前核、腹侧后核、腹侧后外侧核等7个核团均以基质样连接为主。虽然我们独立地绘制了所有丘脑核团，但功能相关的核团与隔室水平的偏差相匹配。我们验证了这些结果与以前的丘脑纹状体束跟踪研究在非人类灵长类动物和其他物种，可靠的数据是可用的，都同意我们的措施的结构连接。在18个丘脑核团中，基质样连接是偏侧的（左半球>右半球），与利手性、扩散协议、性别或核团是以纹状体为主还是以基质为主无关。纹状体-苍白球-丘脑结构连接中的隔室特异性偏差表明，通过纹状体样或基质样体素路由CSTC环是组织和调节脑网络的基本机制。我们基于MRI的人类纹状体-丘脑连接性评估匹配并扩展了先前在动物中进行的束追踪研究的结果。隔室水平表征可以改善人类神经病变的定位，并改善GPi和丘脑中的神经外科靶向。
Cortico-striato-thalamo-cortical (CSTC) loops are fundamental organizing units in mammalian brains. CSTCs process limbic, associative, and sensorimotor information in largely separated but interacting networks. CTSC loops pass through paired striatal compartments, striosome (aka patch) and matrix, segregated pools of medium spiny projection neurons with distinct embryologic origins, cortical/subcortical structural connectivity, susceptibility to injury, and roles in behaviors and diseases. Similarly, striatal dopamine modulates activity in striosome and matrix in opposite directions. Routing CSTCs through one compartment may be an anatomical basis for regulating discrete functions. We used differential structural connectivity, identified through probabilistic diffusion tractography, to distinguish the striatal compartments (striosome-like and matrix-like voxels) in living humans. We then mapped compartment-specific projections and quantified structural connectivity between each striatal compartment, the globus pallidus interna (GPi), and 20 thalamic nuclei in 221 healthy adults. We found that striosome-originating and matrix-originating streamlines were segregated within the GPi: striosome-like connectivity was significantly more rostral, ventral, and medial. Striato-pallido-thalamic streamline bundles that were seeded from striosome-like and matrix-like voxels transited spatially distinct portions of the white matter. Matrix-like streamlines were 5.7-fold more likely to reach the GPi, replicating animal tract-tracing studies. Striosome-like connectivity dominated in six thalamic nuclei (anteroventral, central lateral, laterodorsal, lateral posterior, mediodorsal-medial, and medial geniculate). Matrix-like connectivity dominated in seven thalamic nuclei (centromedian, parafascicular, pulvinar-anterior, pulvinar-lateral, ventral lateral-anterior, ventral lateral-posterior, ventral posterolateral). Though we mapped all thalamic nuclei independently, functionally-related nuclei were matched for compartment-level bias. We validated these results with prior thalamostriate tract tracing studies in non-human primates and other species; where reliable data was available, all agreed with our measures of structural connectivity. Matrix-like connectivity was lateralized (left > right hemisphere) in 18 thalamic nuclei, independent of handedness, diffusion protocol, sex, or whether the nucleus was striosome-dominated or matrix-dominated. Compartment-specific biases in striato-pallido-thalamic structural connectivity suggest that routing CSTC loops through striosome-like or matrix-like voxels is a fundamental mechanism for organizing and regulating brain networks. Our MRI-based assessments of striato-thalamic connectivity in humans match and extend the results of prior tract tracing studies in animals. Compartment-level characterization may improve localization of human neuropathologies and improve neurosurgical targeting in the GPi and thalamus.
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影响因子：
3
作者：
Cover KK;Mathur BN
通讯作者：
Mathur BN
健康儿童的丘脑皮质连通性：8至17岁之间的不对称和稳健的发育变化。
DOI：
10.3174/ajnr.a2417
发表时间：
2011-05
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Alkonyi B;Juhász C;Muzik O;Behen ME;Jeong JW;Chugani HT
通讯作者：
Chugani HT
影响因子：
2.8
作者：
Barry, K. M.;Robertson, D.;Mulders, W. H. A. M.
通讯作者：
Mulders, W. H. A. M.
影响因子：
4.3
作者：
Jaquins-Gerstl A;Nesbitt KM;Michael AC
通讯作者：
Michael AC
影响因子：
2.9
作者：
Crittenden JR;Graybiel AM
通讯作者：
Graybiel AM