Body mass index from age 15 years onwards and muscle mass, strength, and quality in early old age: findings from the MRC National Survey of Health and Development.
Body mass index from age 15 years onwards and muscle mass, strength, and quality in early old age: findings from the MRC National Survey of Health and Development.
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从15岁开始的体重指数，早年的肌肉质量，力量和质量：MRC全国健康与发展调查的发现。
DOI：
10.1093/gerona/glu039
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发表时间：
2014-10
期刊：
影响因子：
--
通讯作者：
MRC National Survey of Health and Development Scientific and Data Collection Team
中科院分区：
文献类型：
--
作者：
Cooper R;Hardy R;Bann D;Aihie Sayer A;Ward KA;Adams JE;Kuh D;MRC National Survey of Health and Development Scientific and Data Collection Team
随着越来越多的人在生活中肥胖，目前还不清楚这将对肌肉质量，力量和质量产生什么影响。我们的目的是研究从15岁开始的体重指数（BMI）与老年早期肌肉质量，力量和质量低的关系。来自英国出生队列研究的1,511名男性和女性，在15、20、26、36、43、53和60-64岁时测量BMI，并在60-64岁时进行双能X线吸收扫描。四个二元结果确定了那些在底部性别特异性20%的（a）非典型瘦体重（ALM）指数（千克/平方米），（B）ALM残差（源自性别特异性模型，其中ALM（千克）= β0 + β1身高[米] + β2脂肪质量[千克]），（c）握力（千克），（d）肌肉质量（握力[千克]/手臂瘦体重[千克]）。BMI与每个结果的关联进行了测试。从15岁开始，较高的BMI与较低的ALM几率相关，但与较高的低肌肉质量几率相关（36岁时BMI每增加1个SD，低ALM残差的比值比= 0.50 [95% CI：0.43，0.59]，肌肉质量= 1.50 [1.29，1.75]）。BMI的增加与低ALM指数的可能性较低有关，但与低肌肉质量的可能性较高有关。BMI与握力无关。鉴于全球肥胖患病率的增加，肌肉减少症的跨队列比较需要考虑我们的发现，即BMI的增加与更高的肌肉质量有关，但与握力无关，因此与肌肉质量较低有关。
As more people live more of their lives obese, it is unclear what impact this will have on muscle mass, strength, and quality. We aimed to examine the associations of body mass index (BMI) from age 15 years onwards with low muscle mass, strength, and quality in early old age. A total of 1,511 men and women from a British birth cohort study with BMI measured at 15, 20, 26, 36, 43, 53, and 60–64 years and dual-energy x-ray absorptiometry scans at 60–64 years were included. Four binary outcomes identified those in the bottom sex-specific 20% of (a) appendicular lean mass (ALM) index (kilogram per square meter), (b) ALM residuals (derived from sex-specific models in which ALM (kilogram) = β0 + β1 height [meter] + β2 fat mass [kilogram]), (c) grip strength (kilogram), (d) muscle quality (grip strength [kilogram]/arm lean mass [kilogram]). Associations of BMI with each outcome were tested. Higher BMI from age 15 years was associated with lower odds of low ALM but higher odds of low muscle quality (per 1 SD increase in BMI at 36 years, odds ratio of low ALM residuals = 0.50 [95% CI: 0.43, 0.59], and muscle quality = 1.50 [1.29, 1.75]). Greater gains in BMI were associated with lower odds of low ALM index but higher odds of low muscle quality. BMI was not associated with grip strength. Given increases in the global prevalence of obesity, cross-cohort comparisons of sarcopenia need to consider our findings that greater gains in BMI are associated with higher muscle mass but not with grip strength and therefore with lower muscle quality.
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发表时间：
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影响因子：
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