Cephalic phase insulin release: A review of its mechanistic basis and variability in humans.
Cephalic phase insulin release: A review of its mechanistic basis and variability in humans.
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DOI：
10.1016/j.physbeh.2021.113514
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发表时间：
2021-10-01
影响因子：
2.9
通讯作者：
Lim J
中科院分区：
文献类型：
--
作者：
Pullicin AJ;Glendinning JI;Lim J
头相胰岛素释放（CPIR）是在食物或食物相关刺激刺激的几分钟内发生的胰岛素瞬时脉冲。尽管对人类CPIR进行了数十年的研究，但围绕这一现象的文献主体仍存在争议，部分原因是研究之间的结果相互矛盾。这减缓了对反应的感觉和神经基础及其与健康的整体相关性的理解。本综述旨在研究CPIR研究的最新知识，并确定人类CPIR变异的来源，以指导未来的研究。综述首先定义CPIR，并讨论其在葡萄糖稳态和摄食行为中的假定功能作用。接下来，类型的刺激，已报告引发CPIR，以及在啮齿动物和人类的反应的感觉和神经机制进行了讨论，并确定知识有限的领域。最后，可能有助于观察到的变化CPIR在人类的因素进行了检查，包括实验设计，测试程序，和个人特征。总的来说，口腔刺激似乎是重要的引发CPIR，特别是当与其他感官形式（视觉，嗅觉，体感）相结合。虽然实验设计和测试程序的差异可能解释了一些观察到的研究间和研究内变异性，但个体差异似乎也发挥了重要作用。了解CPIR中这些个体差异的来源将是确定其健康相关性的关键。
Cephalic phase insulin release (CPIR) is a transient pulse of insulin that occurs within minutes of stimulation from foods or food-related stimuli. Despite decades of research on CPIR in humans, the body of literature surrounding this phenomenon is controversial due in part to contradictory findings between studies. This has slowed progress towards understanding the sensory and neural basis of the response, as well as its overall relevance to health. This review aims to examine up-to-date knowledge in CPIR research and identify sources of CPIR variability in humans in an effort to guide future research. The review starts by defining CPIR and discussing its presumed functional roles in glucose homeostasis and feeding behavior. Next, the types of stimuli that have been reported to elicit CPIR, as well as the sensory and neural mechanisms underlying the response in rodents and humans are discussed, and areas where knowledge is limited are identified. Finally, factors that may contribute to the observed variability of CPIR in humans are examined, including experimental design, test procedure, and individual characteristics. Overall, oral stimulation appears to be important for eliciting CPIR, especially when combined with other sensory modalities (vision, olfaction, somatosensation). While differences in experimental design and testing procedure likely explain some of the observed inter- and intra-study variability, individual differences also appear to play an important role. Understanding sources of these individual differences in CPIR will be key for establishing its health relevance.
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影响因子：
4.4
作者：
Cedernaes, Jonathan;Lampola, Lauri;Benedict, Christian
通讯作者：
Benedict, Christian
影响因子：
7.1
作者：
Abdallah, L;Chabert, M;LouisSylvestre, J
通讯作者：
LouisSylvestre, J
影响因子：
4.2
作者：
Peyrot des Gachons C;Breslin PA
通讯作者：
Breslin PA
DOI：
10.1037/h0077782
发表时间：
1981-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
BERRIDGE, K;GRILL, HJ;NORGREN, R
通讯作者：
NORGREN, R
影响因子：
3.7
作者：
ALVAREZ, MA;PORTILLA, L;EZCURRA, E
通讯作者：
EZCURRA, E