Sex and the migraine brain.

Sex and the migraine brain.
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DOI:
10.1016/j.nbd.2014.03.008
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发表时间:
2014-08
影响因子:
6.1
通讯作者:
Burstein R
Burstein R
中科院分区:
医学1区
文献类型:
--
作者:
Borsook D;Erpelding N;Lebel A;Linnman C;Veggeberg R;Grant PE;Buettner C;Becerra L;Burstein R

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大脑对与神经系统发育阶段相关的环境和内部信号有不同的反应。虽然遗传和表观遗传因素会导致病前状态,但女性的荷尔蒙波动可能会改变偏头痛的设定点。性腺激素的周期性激增可能会直接改变整个大脑的神经元、神经胶质细胞和星形胶质细胞的功能。雌激素主要对脑神经系统有兴奋作用,而孕激素则主要有抑制作用。这些变化导致了偏头痛的非稳态负荷,尤其是在女孩青春期开始。
The brain responds differently to environmental and internal signals that relates to the stage of development of neural systems. While genetic and epigenetic factors contribute to a premorbid state, hormonal fluctuations in women may alter the set point of migraine. The cyclic surges of gonadal hormones may directly alter neuronal, glial and astrocyte function throughout the brain. Estrogen is mainly excitatory and progesterone inhibitory on brain neuronal systems. These changes contribute to the allostatic load of the migraine condition that most notably starts at puberty in girls.
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