Sex and the migraine brain.
Sex and the migraine brain.
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DOI:
10.1016/j.nbd.2014.03.008
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发表时间:
2014-08
影响因子:
6.1
通讯作者:
Burstein R
中科院分区:
文献类型:
--
作者:
Borsook D;Erpelding N;Lebel A;Linnman C;Veggeberg R;Grant PE;Buettner C;Becerra L;Burstein R
The brain responds differently to environmental and internal signals that relates to the stage of development of neural systems. While genetic and epigenetic factors contribute to a premorbid state, hormonal fluctuations in women may alter the set point of migraine. The cyclic surges of gonadal hormones may directly alter neuronal, glial and astrocyte function throughout the brain. Estrogen is mainly excitatory and progesterone inhibitory on brain neuronal systems. These changes contribute to the allostatic load of the migraine condition that most notably starts at puberty in girls.
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