Differences in cortical thinning across development among individuals with and without anxiety disorders.
Differences in cortical thinning across development among individuals with and without anxiety disorders.
复制标题
焦虑症患者和非焦虑症患者大脑皮层变薄的差异。
DOI：
10.1002/da.23096
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发表时间：
2021-03
影响因子：
7.4
通讯作者：
Burkhouse KL
中科院分区：
文献类型：
--
作者：
Feurer C;Suor JH;Jimmy J;Klumpp H;Monk CS;Phan KL;Burkhouse KL
焦虑与情绪调节相关区域的皮质厚度异常模式有关。然而，很少有研究探讨了焦虑个体和健康对照（HC）在整个发展过程中的皮质厚度差异，特别是在儿童时期，当皮质变薄开始和焦虑风险增加时。更好地了解焦虑个体中与年龄相关的皮质厚度模式变化对于开发早期识别的合理目标至关重要。目前的研究探讨了年龄如何影响HC和焦虑个体之间皮质厚度模式的差异。参与者包括233名患有焦虑症（n=149）或无精神病理学终身史（n=84）的个体（年龄7-35）。评估了与情绪调节有关的区域[腹内侧前额叶皮层（vmPFC）、头端前扣带回（rACC）和扣带回]的皮质厚度。除左侧前扣带回和右侧前扣带回外，所有区域均随年龄增长而显著变薄。然而，焦虑和HC参与者的变薄率不同，焦虑参与者的右VMPFC变薄率较慢。显著性区域分析表明，焦虑，相对于HC，参与者在11岁之前表现出较薄的右VMPFC，但在24岁之后表现出较厚的右VMPFC。目前的研究结果表明，焦虑的人没有表现出正常的右vmPFC皮质变薄，这可能会导致他们表现出更薄的vmPFC在童年中期和更厚的vmPFC在成年期相比，HC。这些发现可能提供合理的目标，根据发展阶段不同的焦虑风险的识别。
Anxiety is associated with aberrant patterns of cortical thickness in regions implicated in emotion regulation. However, few studies have examined cortical thickness differences between individuals with anxiety and healthy controls (HCs) across development, particularly during childhood when cortical thinning begins and anxiety risk increases. A better understanding of age-related changes in cortical thickness patterns among anxious individuals is essential to develop plausible targets for early identification. The current study examined how age impacted differences in cortical thickness patterns between HCs and anxious individuals. Participants included 233 individuals (ages 7–35) with a current anxiety disorder (n=149) or no lifetime history of psychopathology (n=84). Cortical thickness of regions that are implicated in emotion regulation [ventromedial prefrontal cortex (vmPFC), rostral anterior cingulate (rACC), and insula] were assessed. All regions showed significant thinning with age, except left rACC and right insula. However, rates of thinning differed among anxious and HC participants, with anxious participants demonstrating slower rates of right vmPFC thinning. Regions of significance analyses indicated that anxious, relative to HC, participants exhibited thinner right vmPFC before age 11, but thicker right vmPFC after age 24. Current findings suggest that anxious individuals do not demonstrate normative right vmPFC cortical thinning, which may lead them to exhibit both thinner vmPFC in middle childhood and thicker vmPFC in adulthood compared to HCs. These findings may provide plausible targets for identification of anxiety risk that differ based on developmental stage.
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影响因子：
5.7
作者：
Ducharme S;Albaugh MD;Nguyen TV;Hudziak JJ;Mateos-Pérez JM;Labbe A;Evans AC;Karama S;Brain Development Cooperative Group
通讯作者：
Brain Development Cooperative Group
影响因子：
19.9
作者：
Etkin, Amit;Egner, Tobias;Kalisch, Raffael
通讯作者：
Kalisch, Raffael
影响因子：
2.3
作者：
Eleonora, Maggioni;Giuseppe, Delvecchio;Paolo, Brambilla
通讯作者：
Paolo, Brambilla
DOI：
10.1016/j.chc.2005.06.003
发表时间：
2005-10-01
影响因子：
2.4
作者：
Costello, EJ;Egger, HL;Angold, A
通讯作者：
Angold, A
影响因子：
3.7
作者：
Ducharme, Simon;Albaugh, Matthew D.;Karama, Sherif
通讯作者：
Karama, Sherif