Altered expression of glial and synaptic markers in the anterior hippocampus of behaviorally depressed female monkeys.
Altered expression of glial and synaptic markers in the anterior hippocampus of behaviorally depressed female monkeys.
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DOI：
10.1016/j.neulet.2014.01.012
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发表时间：
2014-03-20
影响因子：
2.5
通讯作者：
Shively CA
中科院分区：
文献类型：
--
作者：
Willard SL;Hemby SE;Register TC;McIntosh S;Shively CA
海马前部与情绪功能有关，抑郁症患者海马体积减小。我们报道了行为抑郁的成年雌性食蟹猕猴的前海马齿状回（DG）和谷氨酰胺（CA）1的神经细胞体积和胶质细胞数量减少。为了确定行为抑郁和非行为抑郁的成年雌性猴子之间形态计量学和行为差异的生化相关性，我们评估了海马前部DG、CA3和CA1的胶质和突触转录物以及蛋白质水平。神经胶质原纤维酸性蛋白（GFAP）升高，嗜脊髓蛋白和突触后密度(PSD)-95蛋白降低。GFAP与CA1中嗜脊髓蛋白和PSD-95蛋白呈负相关。GFAP的基因表达与CA1中观察到的蛋白变化平行，并且与抑郁猴子的血清雌二醇水平呈负相关。这些结果表明，雌性灵长类动物的行为抑郁伴随着CA1的星形细胞和突触蛋白的改变。此外，这些发现表明雌激素在调节星形胶质细胞介导的突触可塑性损伤中的潜在作用。
The anterior hippocampus is associated with emotional functioning and hippocampal volume is reduced in depression. We reported reduced neuropil volume and number of glia in the dentate gyrus (DG) and cornu ammonis (CA)1 of the anterior hippocampus in behaviorally depressed adult female cynomolgus macaques. To determine the biochemical correlates of morphometric and behavioral differences between behaviorally depressed and nondepressed adult female monkeys, glial and synaptic transcripts and protein levels were assessed in the DG, CA3 and CA1 of the anterior hippocampus. Glial fibrillary acidic protein (GFAP) was increased whereas spinophilin and postsynaptic density (PSD)-95 protein were decreased in the CA1 of depressed monkeys. GFAP was reciprocally related to spinophilin and PSD-95 protein in the CA1. Gene expression of GFAP paralleled the protein changes observed in the CA1 and was inversely related to serum estradiol levels in depressed monkeys. These results suggest that behavioral depression in female primates is accompanied by astrocytic and synaptic protein alterations in the CA1. Moreover, these findings indicate a potential role for estrogen in modulating astrocyte-mediated impairments in synaptic plasticity.
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影响因子：
5.3
作者：
Shivel, Carol A.;Willard, Stephanie L.
通讯作者：
Willard, Stephanie L.
DOI：
10.1523/jneurosci.3021-09.2010
发表时间：
2010-01-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Goldstein JM;Jerram M;Abbs B;Whitfield-Gabrieli S;Makris N
通讯作者：
Makris N
影响因子：
10.6
作者：
Shively, CA;LaberLaird, K;Anton, RF
通讯作者：
Anton, RF
影响因子：
8.2
作者：
Shively, Carol A.;Musselman, Dominique L.;Willard, Stephanie L.
通讯作者：
Willard, Stephanie L.
影响因子：
7.6
作者：
Boldrini, Maura;Santiago, Adrienne N.;Mann, J. John
通讯作者：
Mann, J. John