Behavioral and neurobiological characteristics of social stress versus depression in nonhuman primates.
Behavioral and neurobiological characteristics of social stress versus depression in nonhuman primates.
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DOI：
10.1016/j.expneurol.2011.09.026
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发表时间：
2012-01
影响因子：
5.3
通讯作者：
Willard, Stephanie L.
中科院分区：
文献类型：
--
作者：
Shivel, Carol A.;Willard, Stephanie L.
关键词：
综述的重点是压力与抑郁的行为和生理表现。本文的目的是评估使用压力模型作为抑郁症替代物的概念方法。社会压力与抑郁症有许多共同的特点，并相互促进。两者都对社会关系和生活质量产生不利影响，并增加患其他疾病的风险。然而，它们不是相同的结构。在人类和非人类灵长类动物中，压力个体的行为和神经生物学与抑郁个体不同。社会压力和抑郁个体在压力生理学上的一些相似之处已经被用来支持使用压力动物作为抑郁模型，并且已经从抑郁的压力模型中学到了很多东西。然而，这里回顾的研究也表明，抑郁状态也有不同的特点比压力状态，研究差异可能是重要的，以进一步了解这些结构以及它们之间的相互关系。
The focus of the review is on the behavioral and physiological manifestations of stress versus depression. The purpose of the review is to evaluate the conceptual approach of using stress models as surrogates for depression. Social stress and depression have many characteristics in common and promote each other. Both have adverse effects on social relationships and the quality of life, and increase risk of other diseases. However, they are not the same constructs. In human and nonhuman primates, the behavior and neurobiology of stressed individuals differ from that of depressed individuals. Some similarities in stress physiology in socially stressed and depressed individuals have been used to support the use of stressed animals as models of depression, and much has been learned from stress models of depression. However, the studies reviewed here also suggest that the depressed state also has different characteristics than the stressed state, and studying the differences may be important to furthering our understanding of each of these constructs as well as their mutual relationship.
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