Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared with 2000-2004.
Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared with 2000-2004.
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DOI：
10.3945/ajcn.2008.26182
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发表时间：
2008-12
期刊：
影响因子：
--
通讯作者：
Yetley EA
中科院分区：
文献类型：
--
作者：
Looker AC;Pfeiffer CM;Lacher DA;Schleicher RL;Picciano MF;Yetley EA
尚未描述美国人群血清25-羟基维生素D（25 OHD）浓度的变化。使用国家健康和营养检查调查（NHANES）的数据比较2000-2004年与1988-1994年美国人群的血清25 OHD浓度，并确定影响因素。在NHANES 2000-2004和NHANES III（1988-1994）的20，289名参与者和18，158名参与者中，使用放射免疫测定试剂盒测量血清25 OHD。根据测量的身高和体重计算体重指数（BMI）。通过问卷调查评估牛奶摄入量和防晒措施。通过使用当前检测方法重新分析来自NHANES III的150份储存血清标本，评估了检测差异。NHANES 2000-2004中校正的平均血清25 OHD浓度显著低于NHANES III 5-20 nmol/L。考虑到测定变化后，NHANES 2000-2004中的年龄校正平均值在大多数男性中仍显著较低（5-9 nmol/L），但在大多数女性中并非如此。在一项研究子样本中，考虑到测定差异的混杂效应，平均血清25 OHD变化约10 nmol/L，而考虑到可能与维生素D状态真实的变化相关的因素（BMI、牛奶摄入量和防晒）的变化，平均值变化1-1.6 nmol/L。总体而言，2000-2004年的平均血清25 OHD低于1988-1994年。在大多数人群中，与维生素D状态变化无关的测定变化占了大部分差异。在一个成人亚组中，BMI、牛奶摄入量和防晒措施的综合变化似乎有助于维生素D状态的真实的下降。
Changes in serum 25-hydroxyvitamin D (25OHD) concentrations in the US population have not been described. Use data from the National Health and Nutrition Examination Surveys (NHANES) to compare serum 25OHD concentrations in the US population in 2000–2004 versus 1988–1994, and to identify contributing factors. Serum 25OHD was measured with a radioimmunoassay kit in 20,289 participants in NHANES 2000–2004 and 18,158 participants in NHANES III (1988–1994). Body mass index (BMI) was calculated from measured height and weight. Milk intake and sun protection were assessed by questionnaire. Assay differences were assessed by re-analyzing 150 stored sera specimens from NHANES III with the current assay. Age-adjusted mean serum 25OHD concentrations were significantly lower by 5–20 nmol/L in NHANES 2000–2004 than in NHANES III. After accounting for assay shifts, age-adjusted means in NHANES 2000–2004 remained significantly lower (by 5–9 nmol/L) in most males, but not in most females. In a study subsample, accounting for the confounding effects of assay differences changed mean serum 25OHD by ~10 nmol/L, while accounting for changes in the factors likely related to real changes in vitamin D status (BMI, milk intake, and sun protection) changed means by 1–1.6 nmol/L. Overall, mean serum 25OHD was lower in 2000–2004 than 1988–1994. Assay changes unrelated to changes in vitamin D status accounted for much of the difference in most population groups. In an adult subgroup, combined changes in BMI, milk intake and sun protection appeared to contribute to a real decline in vitamin D status.
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影响因子：
120.7
作者：
Flegal, KM;Carroll, MD;Johnson, CL
通讯作者：
Johnson, CL
影响因子：
7.1
作者：
Weng, Francis L.;Shults, Justine;Zemel, Babette S.
通讯作者：
Zemel, Babette S.
影响因子：
5.8
作者：
Binkley, N;Krueger, D;Drezner, MK
通讯作者：
Drezner, MK
影响因子：
120.7
作者：
Ogden, CL;Carroll, MD;Flegal, KM
通讯作者：
Flegal, KM
影响因子：
4.2
作者：
Bodnar, Lisa M.;Simhan, Hyagriv N.;Roberts, James M.
通讯作者：
Roberts, James M.