Dynamic imaging and pathological changes in pig liver after MR-guided microwave ablation.
Dynamic imaging and pathological changes in pig liver after MR-guided microwave ablation.
复制标题
DOI：
10.1186/s12885-018-4157-4
复制
发表时间：
2018-04-06
期刊：
影响因子：
3.8
通讯作者：
Wu P
中科院分区：
文献类型：
--
作者：
Dong J;Geng X;Yang Y;Cai X;Hu P;Xia L;Zhang B;Wu P
磁共振（MR）引导下微波消融是一种成熟的肿瘤治疗技术，尤其是肝癌。然而，目前还没有关于消融后观察到的MR图像和组织学变化的详细报告。本研究旨在动态映射消融后的病理变化和MR图像上发生的变化。我们对10头五指山猪进行了MR引导微波消融，并在消融后立即（0周）和消融后1、2、3和4周进行了MR扫描。我们将MR图像上评估的消融与随访期间获得的组织标本进行了比较。消融区的平均长度和宽度在MR图像上分别为4.27 cm和2.42 cm，在组织标本上分别为4.26 cm和2.45 cm（P > 0.05）。消融后即刻，在消融区中心观察到碳化和空洞。周围层细胞坏死，但保持其原始形状。最外层发炎，但逐渐表现出纤维化特征。MR图像准确地反映了消融术后的组织学变化。本研究中概述的肝脏消融的动态成像和病理特征将为MR引导微波消融后的患者随访提供有用的参考。本文的在线版本（10.1186/s12885-018-4157-4）包含补充材料，可供授权用户使用。
Magnetic resonance (MR)-guided microwave ablation is a well-developed technique for the treatment of tumors, especially hepatic carcinomas. However, there are no detailed reports on the changes in the MR images and histology observed after the ablation. This study aimed to dynamically map the pathological changes after ablation and the changes occurring on MR images. We performed MR-guided microwave ablation in 10 Wuzhishan pigs and obtained an MR scan immediately after ablation (0 weeks) and at 1, 2, 3, and 4 weeks after ablation. We compared the ablation assessed on MR images to tissue specimens obtained during follow-up. We found no significant difference in the ablation size between MR images and tissue specimens; the mean length and width of the ablated zone were 4.27 cm and 2.42 cm, respectively, on MR images and 4.26 cm and 2.45 cm, respectively, on specimens (P > 0.05). Immediately after ablation, carbonization and cavities were observed in the center of the ablation zone. Surrounding layer cells were necrotic but maintained their original shapes. The outermost layer was inflamed, but gradually showed fibrotic characteristics. The MR images accurately reflected the exact histological tissue changes after the ablation procedure. The dynamic imaging and pathological features of liver ablation outlined in this study will provide a useful reference for patient follow-up after MR-guided microwave ablation. The online version of this article (10.1186/s12885-018-4157-4) contains supplementary material, which is available to authorized users.
登录
查看更多内容
影响因子：
5
作者：
Kierans, Andrea S.;Elazzazi, Mohamed;Semelka, Richard C.
通讯作者：
Semelka, Richard C.
影响因子：
254.7
作者：
Torre, Lindsey A.;Bray, Freddie;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin
影响因子：
3.3
作者：
Yu, Jie;Liang, Ping;Wang, Yang
通讯作者：
Wang, Yang
影响因子：
3.1
作者：
Jones, Robert P.;Kitteringham, Neil R.;Malik, Hassan Z.
通讯作者：
Malik, Hassan Z.
影响因子：
4.4
作者：
Morikawa, S;Inubushi, T;Fujimura, M
通讯作者：
Fujimura, M