Evaluation of white blood cell count as a possible prognostic marker for oral cancer.
Evaluation of white blood cell count as a possible prognostic marker for oral cancer.
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DOI：
10.1186/1758-3284-3-13
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发表时间：
2011-02-27
期刊：
影响因子：
--
通讯作者：
Grätz KW
中科院分区：
文献类型：
--
作者：
Kruse AL;Luebbers HT;Grätz KW
似乎有越来越多的证据表明炎症会导致癌症。对于几种癌症，已报告与白色血细胞（WBC）计数相关。到目前为止，尚未对口腔癌和WBC进行研究。因此，本研究的目的是观察白细胞计数是否可以作为口腔癌复发或转移的预后标志物。对278例口腔癌患者的术前WBC计数与临床病理信息进行比较：年龄、性别、T状态、N状态、复发、转移、随访时间和至复发或转移出现的时间。在278例患者中，48例复发，24例继发肿瘤，46例颈部转移，14例远处转移。平均随访时间为35.97个月（范围：12-107个月）。在0.05水平下，T状态（0.046）的Pearson相关性显著，但N状态（0.121）的Pearson相关性不显著。未发现WBC计数与复发或转移的发展之间存在显著相关性。总之，我们的研究结果表明，白细胞计数升高似乎不是复发或进一步转移的预测因子。建议进一步研究癌前病变和HPV阳性口腔鳞状细胞癌患者的白细胞计数。
There seems to be increasing evidence that inflammation leads to cancer. For several cancers, an association with white blood cell (WBC) count has been reported. So far, no studies have been performed for cancer of the oral cavity and WBC. Therefore, the aim of the present study was to look at whether WBC count can be used as a prognostic marker for recurrence or metastases for oral cancer. For 278 patients with oral cancer, the preoperative WBC count was compared with the clinicopathological information: age, gender, T-status, N-status, recurrence, metastases, follow-up time, and time till recurrence or metastases appeared. Out of 278 patients, 48 developed recurrence, 24 second tumors, 46 cervical metastases, and 14 distant metastases. The mean follow-up time was 35.97 months (range: 12-107 months). Significant Pearson correlation at the 0.05 level could be found for the T-status (0.046), but not for the N status (0.121). No significant correlation could be found between WBC count and the development of recurrence or metastases. In conclusion, our findings demonstrate that elevated WBC count does not seem to be a predictor for recurrence or for further metastases. Further research is recommended to investigate the WBC count in precancerous lesions and in HPV positive patients with oral SCC.
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影响因子：
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作者：
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