Boosting transcription by transcription: enhancer-associated transcripts.
Boosting transcription by transcription: enhancer-associated transcripts.
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DOI：
10.1007/s10577-013-9384-6
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发表时间：
2013-12
影响因子：
2.6
通讯作者：
Chadwick, Brian P.
中科院分区：
文献类型：
--
作者：
Darrow, Emily M.;Chadwick, Brian P.
关键词：
传统上，增强子被认为是位于距离启动子一定距离的DNA序列，它以顺式和方向无关的方式作用，增加对特定启动子的利用，从而调节基因表达。在过去的十年里，在了解这些遥远的元件如何与目标启动子相互作用方面取得了很大进展，但转录如何增强仍然是一个积极研究的对象。最近的报告揭示了增强子转录和转录的普遍性和多样性，并支持两者作为关键因子，在增强子功能中具有不同的、但不是相互排斥的作用。分离转录对局部染色质景观的原因和影响，以及理解增强子转录在长范围相互作用中的作用是需要额外关注的挑战。在这篇综述中，我们通过突出最近的几篇Erna论文来关注增强子转录的可能功能，并在其他增强子研究的背景下，推测增强子转录在调节差异基因表达中的作用。
Enhancers are traditionally viewed as DNA sequences located some distance from a promoter that act in cis and in an orientation-independent fashion to increase utilization of specific promoters and thereby regulate gene expression. Much progress has been made over the last decade toward understanding how these distant elements interact with target promoters, but how transcription is enhanced remains an object of active inquiry. Recent reports convey the prevalence and diversity of enhancer transcription and transcripts and support both as key factors with mechanistically distinct, but not mutually exclusive roles in enhancer function. Decoupling the causes and effects of transcription on the local chromatin landscape and understanding the role of enhancer transcripts in the context of long-range interactions are challenges that require additional attention. In this review we focus on the possible functions of enhancer transcription by highlighting several recent eRNA papers and, within the context of other enhancer studies, speculate on the role of enhancer transcription in regulating differential gene expression.
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