3D magnetic resonance fingerprinting for rapid simultaneous T1, T2, and T1ρ volumetric mapping of human articular cartilage at 3 T.
3D magnetic resonance fingerprinting for rapid simultaneous T1, T2, and T1ρ volumetric mapping of human articular cartilage at 3 T.
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定量MRI可以检测软骨中的早期生化变化;然而，常规技术仅测量一个参数（例如，T1、T2和T1ρ），同时相对较慢。我们实施了3D磁共振指纹（3D-MRF）技术，在9分钟内对膝关节软骨中的T1、T2和T1ρ进行同步体积标测。有前途。3 T的3D-MRF脉冲序列。11个健康志愿者（平均年龄：53 ± 9岁）和5例轻度膝关节OA患者（KL：2，平均年龄：60 ± 4）和NIST/ISMRM系统体模质子密度（PD）图像，并在NIST/ISMRM系统体模以及人膝内侧（MFC）和外侧（LFC）股骨、内侧（MTC）和外侧（LTC）胫骨中估计T1、T2、T1ρ弛豫时间和B1+，和髌骨软骨（PC）。使用Bland-Altman图分析，在体模中评估了所提出技术的重复性和再现性。采用变异系数（CV）和均方根CV（rmsCV）评估受试者内重复性。使用Mann-Whitney U检验评估健康受试者和轻度膝关节OA患者之间的差异。NIST/ISMRM体模中的Bland-Altman图显示，同一3 T扫描仪的两次扫描之间的平均差异为0.001 ± 015%、1.2 ± 7.1%和0.47 ± 3%（重复性），在两台不同3 T扫描仪上采集的扫描之间分别为0.002 ± 015%、0.62 ± 10.5%和0.97 ± 14%（重现性）分别为T1、T2和T1ρ。体内膝关节研究显示出极好的重复性，T1、T2和T1ρ的rmsCV分别小于1%、2%和1%。轻度膝关节骨性关节炎患者的T1ρ弛豫时间显著高于健康人（p < 0.05）。所提出的3D-MRF序列是快速的、可再现的、对B1+不均匀性具有鲁棒性的，并且可以在临床可行的扫描时间内在单次扫描中同时测量膝关节的T1、T2、T1ρ和B1+体积图。在这项研究中，我们实施了一种3D磁共振指纹（3D MRF）技术，在9分钟内对膝关节软骨中的T1、T2和T1ρ进行同步体积标测。所提出的技术用于定量评估软骨以早期检测OA。
Quantitative MRI can detect the early biochemical changes in the cartilage; however, the conventional techniques only measure one parameter (e.g., T1, T2, and T1ρ) at a time while being comparatively slow. We implement a 3D-magnetic resonance fingerprinting (3D-MRF) technique for simultaneous, volumetric mapping of T1, T2, and T1ρ in the knee articular cartilage under 9 minutes. Prospective. 3D-MRF pulse sequence for 3T. 11 healthy volunteers (mean age: 53 ± 9) and 5 mild knee OA patients (KL:2, mean age: 60 ± 4) and NIST/ISMRM system phantom Proton density (PD) image, and T1, T2, T1ρ relaxation times, and B1+ were estimated in NIST/ISMRM system phantom as well as the human knee medial (MFC) and lateral (LFC) femur, medial (MTC) and lateral (LTC) tibia, and patellar cartilages (PC). The repeatability and reproducibility of the proposed technique were assessed in the phantom using the analysis of the Bland-Altman plots. The intra-subject repeatability was assessed with the coefficient of variation (CV), and the root mean square CV (rmsCV). Mann-Whitney U test was used to assess the difference between healthy subjects and mild knee OA patients. The Bland-Altman plots in the NIST/ISMRM phantom demonstrated an average difference of 0.001 ± 015%, 1.2 ± 7.1%, and 0.47 ± 3% between two scans from the same 3T scanner (repeatability), and 0.002 ± 015%, 0.62 ± 10.5%, and 0.97 ± 14% between the scans acquired on two different 3T scanners (reproducibility) for T1, T2, and T1ρ, respectively. The in-vivo knee study showed excellent repeatability with rmsCV less than 1%, 2%, and 1% for T1, T2, and T1ρ, respectively. T1ρ relaxation time in the mild knee OA patients was significantly higher (p < 0.05) than in healthy subjects. The proposed 3D-MRF sequence is fast, reproducible, robust to B1+ inhomogeneity, and can simultaneously measure the T1, T2, T1ρ, and B1+ volumetric maps of the knee joint in a single scan within clinically feasible scan time. In this study, we implemented a 3D magnetic resonance fingerprinting (3D MRF) technique for simultaneous, volumetric mapping of T1, T2, and T1ρ in the knee articular cartilage under 9 minutes. The proposed technique for the quantitative assessment of the cartilage for early detection of OA.
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影响因子：
16.6
作者：
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通讯作者：
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影响因子：
3.3
作者：
Ordidge, RJ;Wylezinska, M;Franconi, F
通讯作者：
Franconi, F