Xerosis cutis and associated co-factors in women with prurigo nodularis.
Xerosis cutis and associated co-factors in women with prurigo nodularis.
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DOI：
10.1590/abd1806-4841.20187127
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发表时间：
2018-09
影响因子：
1.7
通讯作者：
Fetil E
中科院分区：
文献类型：
--
作者：
Akarsu S;Ozbagcivan O;Ilknur T;Semiz F;Inci BB;Fetil E
目前关于结节性痒疹相关因素的数据仍不确定，除了特应性易感性。本研究的目的是(1)确定女性结节性痒疹患者干燥症和其他伴发疾病的发生率；(2)根据患者是否伴有干燥症(随后被分成特应性或非特应性干燥症)对这些患者进行人口学、临床和伴随疾病特征的比较。在这项回顾性描述性研究中，80名患有PN的女性根据伴发疾病(皮肤病、全身性疾病、神经性疾病、心因性疾病、混合性疾病或原因不明)进行了分类。结节性痒疹患者中皮肤科63例(78.8%)，全身57例(71.3%)，心理33例(41.3%)，神经系统14例(17.5%)。48例(60%)患者出现干燥症(其中66.7%为非特应性辅助因素)。干燥症患者中混合共因素、皮肤科+全身性因素和皮肤科+全身性+心理因素的比例明显高于非干燥症患者。我们的研究有一定的局限性，如缺乏年龄匹配的对照组，缺乏随访数据，以及干燥症的诊断没有基于客观方法的事实。在超过一半的PN患者中发现了干燥症，并已确定在大多数患者中，干燥症尤其与糖尿病和其他与结节性瘙痒有关的情况有关。
Current data regarding the associated factors of prurigo nodularis are still uncertain, except for atopic predisposition. The purposes of this study were to (1) determine the frequencies of xerosis and other accompanying diseases of female patients with prurigo nodularis; (2) compare the demographic, clinical and accompanying disease characteristics by grouping these patients according to whether they have associated xerosis (who were subsequently subgrouped as atopic or non-atopic) or not. In this retrospective descriptive study, 80 females with PN were categorized according to the accompanying diseases (dermatological, systemic, neurological, psychogenic, mixed, or undetermined origin). A total of 45 associated co-factors including dermatological in 63 (78.8%), systemic in 57 (71.3%), psychological in 33 (41.3%) and neurological co-factors in 14 (17.5%) of all patients with prurigo nodularis were detected. Xerosis was observed in 48 (60%) patients (non-atopic co-factors in 66.7% of them). The ratio of patients with mixed co-factors, dermatological+systemic co-factors and dermatological+systemic+psychological co-factors were found to be significantly higher in patients with xerosis compared to those without xerosis. Our study has certain limitations such as the absence of an age-matched control group, absence of follow-up data and the fact that the diagnosis of xerosis has not been based on objective methods. Xerosis has been identified in more than half of the patients with PN and it has been determined that in most patients xerosis is associated especially with diabetes mellitus and other conditions related to prurigo nodularis.
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DOI：
10.1159/000446049
发表时间：
2016-01-01
期刊：
ITCH - MANAGEMENT IN CLINICAL PRACTICE
影响因子：
--
作者：
Tsianakas, Athanasios;Zeidler, Claudia;Staender, Sonja
通讯作者：
Staender, Sonja
影响因子：
10.3
作者：
Schneider, G;Hockmann, J;Heuft, G
通讯作者：
Heuft, G
影响因子：
6.5
作者：
Hay, Roderick J.;Johns, Nicole E.;Naghavi, Mohsen
通讯作者：
Naghavi, Mohsen
影响因子：
10.3
作者：
Schuhknecht, B.;Marziniak, M.;Staender, S.
通讯作者：
Staender, S.
影响因子：
3.4
作者：
Tan, Wei Sheng;Tey, Hong Liang
通讯作者：
Tey, Hong Liang