Consumer Product Chemicals in Indoor Dust: A Quantitative Meta-analysis of U.S. Studies.
Consumer Product Chemicals in Indoor Dust: A Quantitative Meta-analysis of U.S. Studies.
复制标题
DOI：
10.1021/acs.est.6b02023
复制
发表时间：
2016-10-04
影响因子：
11.4
通讯作者：
Zota, Ami R.
中科院分区：
文献类型：
--
作者：
Mitro, Susanna D.;Dodson, Robin E.;Singla, Veena;Adarnkiewicz, Gary;Elmi, Angelo F.;Tilly, Monica K.;Zota, Ami R.
室内灰尘是商业消费品化学品的储存库，包括许多已知或怀疑对健康有影响的化合物。然而，大多数粉尘暴露研究在小样本中测量很少的化学品。我们系统地检索了关于邻苯二甲酸酯、替代阻燃剂（RFR）、全氟烷基物质（PFAS）、合成香料和环境酚类的美国室内灰尘文献，并估计了在≥3个数据集中测量的45种化学物质的合并几何平均值（GM）和95%置信区间。为了对这些结果进行排名和背景化，我们使用合并的GM来计算来自空气中粉尘摄入、吸入和皮肤吸收的居民摄入量，然后从更安全的消费品候选化学品清单中确定危险特性。我们的研究结果表明，美国室内灰尘始终含有多种化学物质。邻苯二甲酸酯的浓度最高，其次是酚类、RFR、香料和PFAS。几种邻苯二甲酸酯和RFR的居民摄入量最高。我们还发现，灰尘中的许多化学物质具有生殖和内分泌毒性等危险特性。我们提供建议，以最大限度地提高研究的可比性和推进室内暴露科学。这一信息对于制定未来的暴露和健康研究，特别是与累积暴露有关的研究，以及为制定干预措施和公共政策提供证据至关重要。
Indoor dust is a reservoir for commercial consumer product chemicals, including many compounds with known or suspected health effects. However, most dust exposure studies measure few chemicals in small samples. We systematically searched the U.S. indoor dust literature on phthalates, replacement flame retardants (RFRs), perfluoroalkyl substances (PFASs), synthetic fragrances, and environmental phenols and estimated pooled geometric means (GMs) and 95% confidence intervals for 45 chemicals measured in ≥3 data sets. In order to rank and contextualize these results, we used the pooled GMs to calculate residential intake from dust ingestion, inhalation, and dermal uptake from air, and then identified hazard traits from the Safer Consumer Products Candidate Chemical List. Our results indicate that U.S. indoor dust consistently contains chemicals from multiple classes. Phthalates occurred in the highest concentrations, followed by phenols, RFRs, fragrance, and PFASs. Several phthalates and RFRs had the highest residential intakes. We also found that many chemicals in dust share hazard traits such as reproductive and endocrine toxicity. We offer recommendations to maximize comparability of studies and advance indoor exposure science. This information is critical in shaping future exposure and health studies, especially related to cumulative exposures, and in providing evidence for intervention development and public policy.
登录
查看更多内容
影响因子：
9.8
作者：
Abbasi, Golnoush;Saini, Amandeep;Diamond, Miriam L.
通讯作者：
Diamond, Miriam L.
影响因子：
3.7
作者：
Bekö G;Weschler CJ;Langer S;Callesen M;Toftum J;Clausen G
通讯作者：
Clausen G
影响因子：
11.4
作者：
Carignan, Courtney C.;Heiger-Bernays, Wendy;McClean, Michael D.;Roberts, Simon C.;Stapleton, Heather M.;Sjoedin, Andreas;Webster, Thomas F.
通讯作者：
Webster, Thomas F.
影响因子：
11.4
作者：
Dodson, Robin E.;Camann, David E.;Morello-Frosch, Rachel;Brody, Julia G.;Rudel, Ruthann A.
通讯作者：
Rudel, Ruthann A.
影响因子：
11.8
作者：
Allen, Joseph G.;McClean, Michael D.;Webster, Thomas F.
通讯作者：
Webster, Thomas F.