Hydrogen-methane breath testing results influenced by oral hygiene.
Hydrogen-methane breath testing results influenced by oral hygiene.
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DOI：
10.1038/s41598-020-79554-x
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发表时间：
2021-01-08
影响因子：
4.6
通讯作者：
Harnett JE
中科院分区：
文献类型：
--
作者：
Erdrich S;Tan ECK;Hawrelak JA;Myers SP;Harnett JE
氢-甲烷呼吸气体的测量在胃肠病学中广泛用于评估吸收不良综合征和细菌过度生长。提供呼吸测试的实验室在测试前提供有关口腔卫生习惯的可变指导。鉴于口腔生态失调有可能导致呼吸气体的变化，这引起了人们的担忧，即口腔卫生不是当前呼吸测试指南的标准内容。本研究的目的是确定测试前漱口水如何影响氢甲烷呼气测试结果。参与呼吸测试的基线气体升高的参与者被给予洗必泰漱口水。如果在漱口后呼出的氢气或甲烷大量减少，则在测试期间在漱口前后在所有呼吸样本采集点采集呼吸样本。评估数据以确定漱口水如何影响测试结果和诊断状态。在388个连续的氢-甲烷呼吸测试中，24.7%的人出现了可改变的海拔。在同意入选的受试者中，使用洗必泰漱口水导致67%的呼出氢和/或93%的甲烷气体显著减少（p ≤ 0.05）。在某些情况下，这改变了诊断。漱口前和漱口后的平均总气体浓度分别为221.0 ppm和152.1 ppm（p < 0.0001）的氢，和368.9 ppm和249.8 ppm（p < 0.0001）的甲烷。数据表明，在基线时使用单一漱口水返回假阳性诊断的可能性很高。由于口腔卫生习惯引起的气体产生的变化对测试解释和随后的诊断有重大影响。口腔微生态失调在引起胃肠道症状中的作用也需要探索，因为它可能是作为转诊基础的现有疾病的潜在因素。
The measurement of hydrogen–methane breath gases is widely used in gastroenterology to evaluate malabsorption syndromes and bacterial overgrowth. Laboratories offering breath testing provide variable guidance regarding oral hygiene practices prior to testing. Given that oral dysbiosis has the potential to cause changes in breath gases, it raises concerns that oral hygiene is not a standard inclusion in current breath testing guidelines. The aim of this study was to determine how a pre-test mouthwash may impact hydrogen–methane breath test results. Participants presenting for breath testing who had elevated baseline gases were given a chlorhexidine mouthwash. If a substantial reduction in expired hydrogen or methane occurred after the mouthwash, breath samples were collected before and after a mouthwash at all breath sample collection points for the duration of testing. Data were evaluated to determine how the mouthwash might influence test results and diagnostic status. In 388 consecutive hydrogen–methane breath tests, modifiable elevations occurred in 24.7%. Administration of a chlorhexidine mouthwash resulted in significantly (p ≤ 0.05) reduced breath hydrogen in 67% and/or methane gas in 93% of those consenting to inclusion. In some cases, this modified the diagnosis. Mean total gas concentrations pre- and post-mouthwash were 221.0 ppm and 152.1 ppm (p < 0.0001) for hydrogen, and 368.9 ppm and 249.8 ppm (p < 0.0001) for methane. Data suggest that a single mouthwash at baseline has a high probability of returning a false positive diagnosis. Variations in gas production due to oral hygiene practices has significant impacts on test interpretation and the subsequent diagnosis. The role of oral dysbiosis in causing gastrointestinal symptoms also demands exploration as it may be an underlying factor in the presenting condition that was the basis for the referral.
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影响因子：
2.4
作者：
Amou, T.;Hinode, D.;Grenier, D.
通讯作者：
Grenier, D.
影响因子：
7.6
作者：
Gasbarrini, A.;Corazza, G. R.;Tursi, A.
通讯作者：
Tursi, A.
DOI：
10.1073/pnas.0308766101
发表时间：
2004-04-20
影响因子：
11.1
作者：
Lepp, PW;Brinig, MM;Relman, DA
通讯作者：
Relman, DA
影响因子：
4.6
作者：
Grine G;Terrer E;Boualam MA;Aboudharam G;Chaudet H;Ruimy R;Drancourt M
通讯作者：
Drancourt M
影响因子：
4.3
作者：
Gaci, Nadia;Borrel, Guillaume;Brugere, Jean-Francois
通讯作者：
Brugere, Jean-Francois