Quantification of in vivo colonic motor patterns in healthy humans before and after a meal revealed by high-resolution fiber-optic manometry.
Quantification of in vivo colonic motor patterns in healthy humans before and after a meal revealed by high-resolution fiber-optic manometry.
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DOI：
10.1111/nmo.12408
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发表时间：
2014-10
影响因子：
3.5
通讯作者：
Costa M
中科院分区：
文献类型：
--
作者：
Dinning PG;Wiklendt L;Maslen L;Gibbins I;Patton V;Arkwright JW;Lubowski DZ;O'Grady G;Bampton PA;Brookes SJ;Costa M
直到最近，对健康人结肠运动正常模式的研究一直受到活体记录技术分辨率的限制。我们使用了一种新的高分辨率光纤测压系统(72个传感器，间隔1厘米)来记录10名健康受试者的结肠运动活动。在禁食结肠中，根据传播的速度和程度，可以识别出四种类型的传播运动模式：(1)循环运动模式(2-6次/分钟)；(2)短的单运动模式；(3)长的单运动模式；(4)偶有逆行的慢运动模式。在大多数情况下，循环和短的单项运动模式以逆行的方向传播。700KCAL餐后出现第五种运动模式：高波幅传播序列(HAP)，逆行循环运动模式显著增加(5.6±5.4/2 h比34.7±19.8/2 h；p<；0.001)。个体压力事件的持续时间和幅度显著相关。对构成传播运动模式的压力事件的持续时间、梯度和幅度的判别分析和多元分析清楚地区分了两种类型的压力事件：属于HAPS的压力事件和属于所有其他传播运动模式的压力事件。这项工作首次全面描述了由高分辨率测压记录的结肠运动模式，并展示了丰富的逆行传播运动模式。传播的运动模式似乎由两个独立的来源产生，潜在地表明它们来自神经源性或肌源性。
Until recently, investigations of the normal patterns of motility of the healthy human colon have been limited by the resolution of in vivo recording techniques. We have used a new, high-resolution fiber-optic manometry system (72 sensors at 1-cm intervals) to record motor activity from colon in 10 healthy human subjects. In the fasted colon, on the basis of rate and extent of propagation, four types of propagating motor pattern could be identified: (i) cyclic motor patterns (at 2–6/min); (ii) short single motor patterns; (iii) long single motor patterns; and (iv) occasional retrograde, slow motor patterns. For the most part, the cyclic and short single motor patterns propagated in a retrograde direction. Following a 700 kCal meal, a fifth motor pattern appeared; high-amplitude propagating sequences (HAPS) and there was large increase in retrograde cyclic motor patterns (5.6±5.4/2 h vs 34.7±19.8/2 h; p < 0.001). The duration and amplitude of individual pressure events were significantly correlated. Discriminant and multivariate analysis of duration, gradient, and amplitude of the pressure events that made up propagating motor patterns distinguished clearly two types of pressure events: those belonging to HAPS and those belonging to all other propagating motor patterns. This work provides the first comprehensive description of colonic motor patterns recorded by high-resolution manometry and demonstrates an abundance of retrograde propagating motor patterns. The propagating motor patterns appear to be generated by two independent sources, potentially indicating their neurogenic or myogenic origin.
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影响因子：
24.5
作者：
DANIEL, EE
通讯作者：
DANIEL, EE
影响因子：
3.5
作者：
Dinning, P. G.;Zarate, N.;Cook, I. J.
通讯作者：
Cook, I. J.
影响因子：
7.3
作者：
CREMA, A;FRIGO, GM;LECCHINI, S
通讯作者：
LECCHINI, S
影响因子：
3.1
作者：
De Schryver, AMP;Samsom, M;Smout, AIPM
通讯作者：
Smout, AIPM
影响因子：
3.5
作者：
Dinning, P. G.;Wiklendt, L.;Arkwright, J. W.
通讯作者：
Arkwright, J. W.