Measuring the burden of arboviral diseases: the spectrum of morbidity and mortality from four prevalent infections.
Measuring the burden of arboviral diseases: the spectrum of morbidity and mortality from four prevalent infections.
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测量灰烬病毒疾病的负担：四种普遍感染的发病率和死亡率的范围。
DOI：
10.1186/1478-7954-9-1
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发表时间：
2011-01-10
影响因子：
3.3
通讯作者：
King CH
中科院分区：
文献类型：
--
作者：
Labeaud AD;Bashir F;King CH
在全球范围内，节肢动物传播的病毒感染是严重发热性疾病的越来越常见的原因，这种疾病可能发展为长期的身体或认知障碍，或导致过早死亡。由于面临风险的人口众多，有人认为，这些结果代表着当前全球疾病负担评估没有考虑到的重大健康赤字。我们回顾了关于疾病发病率和预后的最新数据，以严格评估黄热病病毒(YFV)、日本脑炎病毒(JEV)、基孔肯雅病毒(CHIKV)和裂谷热病毒(RVFV)造成的疾病负担(以伤残调整寿命年衡量)。我们检索了关于这些病毒的现有文献和官方报告，并结合术语“暴发(S)”、“并发症(S)”、“残疾”、“生活质量”、“DALY”和“QALY”，重点是2000年以来的报告。我们筛选了210项已发表的研究，其中38项入选。采用当前全球疾病负担框架的方法，使用关于急性和慢性后果的平均发病率、病程、发病年龄、死亡率和严重程度的数据来编制2005年的DALY估计数。考虑到现有数据的限制，2005年可归因于YFV、JEV、CHIKV和RVFV的非折扣、未加权DALY估计在300,000至500,000,000之间。在评估的四种病毒中，YFV是最流行的感染，尽管世界上有较高比例的人口生活在有CHIKV和JEV风险的国家。早期死亡率和长期相关的慢性疾病为每种疾病提供了最大的DALY成分。由这些病毒引起的更广为人知的短期病毒性发热综合征在整体DALY评分中所占比例相对较低。疫区卫生系统的局限性无疑导致对虫媒病毒发病率和相关并发症的低估。然而，改进诊断和更好地了解感染的晚期继发性结果，现在可以初步了解这些广泛严重的感染造成的当前疾病负担。虫媒病毒的控制和预防仍然是一个高度优先事项，这既是因为目前的疾病负担，也是因为这些病毒在更大的易感人群中重新出现的重大威胁。
Globally, arthropod-borne virus infections are increasingly common causes of severe febrile disease that can progress to long-term physical or cognitive impairment or result in early death. Because of the large populations at risk, it has been suggested that these outcomes represent a substantial health deficit not captured by current global disease burden assessments. We reviewed newly available data on disease incidence and outcomes to critically evaluate the disease burden (as measured by disability-adjusted life years, or DALYs) caused by yellow fever virus (YFV), Japanese encephalitis virus (JEV), chikungunya virus (CHIKV), and Rift Valley fever virus (RVFV). We searched available literature and official reports on these viruses combined with the terms "outbreak(s)," "complication(s)," "disability," "quality of life," "DALY," and "QALY," focusing on reports since 2000. We screened 210 published studies, with 38 selected for inclusion. Data on average incidence, duration, age at onset, mortality, and severity of acute and chronic outcomes were used to create DALY estimates for 2005, using the approach of the current Global Burden of Disease framework. Given the limitations of available data, nondiscounted, unweighted DALYs attributable to YFV, JEV, CHIKV, and RVFV were estimated to fall between 300,000 and 5,000,000 for 2005. YFV was the most prevalent infection of the four viruses evaluated, although a higher proportion of the world's population lives in countries at risk for CHIKV and JEV. Early mortality and long-term, related chronic conditions provided the largest DALY components for each disease. The better known, short-term viral febrile syndromes caused by these viruses contributed relatively lower proportions of the overall DALY scores. Limitations in health systems in endemic areas undoubtedly lead to underestimation of arbovirus incidence and related complications. However, improving diagnostics and better understanding of the late secondary results of infection now give a first approximation of the current disease burden from these widespread serious infections. Arbovirus control and prevention remains a high priority, both because of the current disease burden and the significant threat of the re-emergence of these viruses among much larger groups of susceptible populations.
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DOI：
10.4269/ajtmh.2010.09-0293
发表时间：
2010-08-01
影响因子：
3.3
作者：
Anyangu, Amwayi S.;Gould, L. Hannah;Breiman, Robert F.
通讯作者：
Breiman, Robert F.
影响因子：
--
作者：
Bacsal, Kristine Enrile;Chee, Soon-Phaik;Flores, John Vincent Policarpio
通讯作者：
Flores, John Vincent Policarpio
影响因子：
3.6
作者：
Balkhy, HH;Schreiber, JR
通讯作者：
Schreiber, JR
DOI：
10.1016/j.trstmh.2008.04.014
发表时间：
2008-12-01
影响因子：
2.2
作者：
Gould, L. Hannah;Osman, Magdi S.;Perea, William
通讯作者：
Perea, William
影响因子：
11.8
作者：
Borgherini, Gianandrea;Poubeau, Patrice;Paganin, Fabrice
通讯作者：
Paganin, Fabrice