Smoking Is Related to Reduced Motivation, But Not Global Cognition, in the First Two Years of Treatment for First Episode Psychosis.
Smoking Is Related to Reduced Motivation, But Not Global Cognition, in the First Two Years of Treatment for First Episode Psychosis.
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吸烟与第一集精神病治疗的前两年中的动机减少，但无关。
DOI：
10.3390/jcm10081619
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发表时间：
2021-04-11
影响因子：
3.9
通讯作者：
Ramsay IS
中科院分区：
文献类型：
--
作者：
Schermitzler B;Miley K;Vinogradov S;Ramsay IS
吸烟在精神障碍患者中非常普遍，即使在疾病的早期也是如此。尼古丁依赖和精神病的神经机制是重叠的，也可能与精神病的神经认知和动机缺陷有关。神经认知和动机都被认为是重要的临床目标，尽管之前关于吸烟对这些特征的影响的研究一直不一致。在这里，我们通过对最初的精神分裂症发作-早期治疗计划(RAISE-ETP)数据集(RAISE-ETP)数据集的二次分析，检验吸烟状况与精神病治疗的头两年神经认知和动机之间的关系。在404名首发精神病患者的样本中，我们检验了线性混合效应模型，将吸烟者与非吸烟者按时间(基线、12个月、24个月)的互动作为全球认知和动机的预测因子。虽然在24个月的治疗过程中，所有人的全球认知和动机都有所增强，但不吸烟的人在动机方面的收获要大得多。这些动机上的变化也与这24个月期间功能的改善相对应。没有观察到吸烟对整体认知的显著影响。我们的发现表明，动机和戒烟可能是首发精神病项目的重要早期治疗目标。
Smoking is highly prevalent in people with psychotic disorders, even in the earliest phases of the illness. The neural mechanisms of nicotine dependence and psychosis overlap and may also be linked to deficits in neurocognition and motivation in psychosis. Both neurocognition and motivation are recognized as important clinical targets, though previous research examining the effects of smoking on these features has been inconsistent. Here, we examine the relationships between smoking status and neurocognition and motivation over the first two years of treatment for psychosis through a secondary analysis of the Recovery After an Initial Schizophrenia Episode–Early Treatment Program (RAISE–ETP) dataset. In a sample of 404 individuals with first-episode psychosis, we examined linear mixed-effects models with the group (smoker vs. non-smoker) by time (baseline, 12-month, 24-month) interaction as a predictor of global cognition and motivation. While all individuals showed enhanced global cognition and motivation over the 24-month course of treatment, non-smokers showed significantly greater gains in motivation. These changes in motivation also corresponded to improvements in functioning over the 24-month period. No significant effects of smoking were observed for global cognition. Our findings suggest that motivation and smoking cessation may be important early treatment targets for first-episode psychosis programs.
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DOI：
10.1176/appi.ajp.2011.10081209
发表时间：
2011-08
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Carrión RE;Goldberg TE;McLaughlin D;Auther AM;Correll CU;Cornblatt BA
通讯作者：
Cornblatt BA
影响因子：
4.5
作者：
Gard, David E.;Fisher, Melissa;Vinogradov, Sophia
通讯作者：
Vinogradov, Sophia
影响因子：
4.5
作者：
Foussias, G.;Siddiqui, I.;Remington, G.
通讯作者：
Remington, G.
影响因子：
9.5
作者：
Lally, John;Spaducci, Gilda;Gaughran, Fiona
通讯作者：
Gaughran, Fiona
影响因子：
4.8
作者：
Grossman, Michael;Bowie, Christopher R.;Iyer, Srividya N.
通讯作者：
Iyer, Srividya N.