Triglyceride-mediated influence of serum angiopoietin-like protein 8 on subclinical atherosclerosis in type 2 diabetic patients: results from the GDMD study in China.
Triglyceride-mediated influence of serum angiopoietin-like protein 8 on subclinical atherosclerosis in type 2 diabetic patients: results from the GDMD study in China.
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甘油三酯介导的血清血管生成素样蛋白8对2型糖尿病患者亚临床动脉粥样硬化的影响：中国GDMD研究的结果
DOI：
10.1186/s12933-018-0687-y
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发表时间：
2018-07-15
影响因子：
9.3
通讯作者：
Song J
中科院分区：
文献类型：
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作者：
Zheng T;Ge B;Liu H;Chen B;Qin L;Xiao L;Song J
高脂血症、胰岛素抵抗和高血糖是2型糖尿病患者动脉粥样硬化的危险因素。血管生成素样蛋白8（ANGPTL 8）是一种新发现的与这些危险因素相关的肝源性激素。因此，我们的目的是探讨血清ANGPTL 8水平与2型糖尿病亚临床动脉粥样硬化之间的相关性。我们测量了（1）对照受试者（n = 100）、（2）无亚临床动脉粥样硬化的2型糖尿病患者（n = 100）和（3）有亚临床动脉粥样硬化的2型糖尿病患者（n = 100）的血清ANGPTL 8、血脂、血糖、颈总动脉内膜中层厚度（c-IMT）并计算胰岛素抵抗的稳态模型评估。2型糖尿病伴亚临床动脉粥样硬化组ANGPTL 8和甘油三酯（TG）水平显著高于2型糖尿病不伴亚临床动脉粥样硬化组和对照组（P < 0.001）。ANGPTL 8与2型糖尿病患者的年龄、TG、糖尿病病程和c-IMT呈正相关。Logistic回归分析显示，ANGPTL 8在2型糖尿病患者中发生亚临床动脉粥样硬化的几率较高[比值比（OR）2.90，95%可信区间（CI）1.48-5.70，P = 0.002]。中介作用分析表明TG在ANGPTL 8与c-IMT的关系中起部分中介作用。TG部分介导ANGPTL 8与c-IMT的正相关关系。我们的数据提供了ANGPTL 8和亚临床动脉粥样硬化之间强有力联系的第一个证据，表明ANGPTL 8是2型糖尿病亚临床动脉粥样硬化的新生物标志物。
Hypertriglyceridemia, insulin resistance and hyperglycemia are risk factors for atherosclerosis in type 2 diabetes. Angiopoietin-like protein 8 (ANGPTL8) is a newly identified liver-derived hormone related to these risk factors. Hence, we aimed to explore the correlations between serum levels of ANGPTL8 and subclinical atherosclerosis in type 2 diabetes. We measured serum ANGPTL8, blood lipids, blood glucose, common carotid artery Intima-Media Thickness (c-IMT) and calculated homeostasis model assessment of insulin resistance in (1) control subjects (n = 100), (2) type 2 diabetic patients without subclinical atherosclerosis (n = 100), and (3) type 2 diabetic patients with subclinical atherosclerosis (n = 100). Serum levels of ANGPTL8 and triglyceride (TG) were significantly increased in type 2 diabetic patients with subclinical atherosclerosis as compared with type 2 diabetic patients without subclinical atherosclerosis and control subjects (P < 0.001). ANGPTL8 was positively associated with age, TG, diabetes duration, and c-IMT in type 2 diabetes. Logistic regression analysis revealed that ANGPTL8 had higher odds of having subclinical atherosclerosis [odds ratio (OR) 2.90, 95% confidence interval (CI) 1.48–5.70, P = 0.002] in type 2 diabetes. Mediation analysis indicated that TG acted as a partial mediator in the relationship between ANGPTL8 and c-IMT. TG partially mediates the positive relationship between ANGPTL8 and c-IMT. Our data provide the first evidence for a strong link between ANGPTL8 and subclinical atherosclerosis, suggesting ANGPTL8 to be a new biomarker for subclinical atherosclerosis in type 2 diabetes.
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影响因子：
9.3
作者：
Chen CC;Susanto H;Chuang WH;Liu TY;Wang CH
通讯作者：
Wang CH
影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
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作者：
Yue S;Wu J;Zhang J;Liu L;Chen L
通讯作者：
Chen L
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Yu X
影响因子：
6.9
作者：
Guo, Kaifeng;Lu, Junxi;Jia, Weiping
通讯作者：
Jia, Weiping