Effects of stress and depression on inflammatory immune parameters in pregnancy.

Effects of stress and depression on inflammatory immune parameters in pregnancy.
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DOI:
10.1016/j.ajog.2014.06.042
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发表时间:
2014-09
影响因子:
9.8
通讯作者:
Christian, Lisa M.
Christian, Lisa M.
中科院分区:
医学1区
文献类型:
--
作者:
Christian, Lisa M.

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有大量的文献将心理压力与不良妊娠结局,特别是早产联系起来。相对而言,很少有研究探讨了解释这些关联的潜在生物学机制。注意炎症过程是必要的。目前的论文描述了新的研究表明,在非怀孕的人类和动物中,心理压力和痛苦(即,抑郁症状)预测人类妊娠中炎症过程的失调。这包括循环炎性细胞因子的升高,对体内生物学挑战的过度炎症反应,以及对心理挑战的更强烈的炎症反应。需要在这一领域继续进行研究,以确定这种应激诱导的免疫失调对分娩结局以及孕产妇健康和胎儿发育的影响。
There is a substantial body of literature linking psychological stress to adverse pregnancy outcomes, particularly preterm birth. Comparatively few studies have examined potential biological mechanisms explaining these associations. Attention to inflammatory processes is warranted. The current paper describes emerging studies demonstrating that, as in nonpregnant humans and animals, psychological stress and distress (i.e., depressive symptoms) predict dysregulation of inflammatory processes in human pregnancy. This includes elevations in circulating inflammatory cytokines, exaggerated inflammatory responses to in vivo biological challenges, and more robust inflammatory responses to psychological challenges. Continued research in this area is needed to determine the implications of such stress-induced immune dysregulation for birth outcomes as well as maternal health and fetal development.
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