Ciliary muscle thickness in adults with Down syndrome.
Ciliary muscle thickness in adults with Down syndrome.
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成年唐氏综合征患者的睫状肌厚度
DOI：
10.1111/opo.12974
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发表时间：
2022-07
影响因子：
2.9
通讯作者：
Kao, Chiu-Yen
中科院分区：
文献类型：
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作者：
Anderson, Heather A.;Bailey, Melissa D.;Manny, Ruth E.;Kao, Chiu-Yen
研究了睫状肌厚度（CMT）、年龄和屈光不正之间的关系，以确定CMT是否与其他眼前解剖结构一样，在唐氏综合征（DS）成人中有所不同。对33例成人退行性椎体滑移患者的CMT进行了前段光学相干断层成像。分析右眼睫状体麻痹后45分钟（1% tropicamide, 2.5% phenylephrine）的图像，计算巩膜骨刺后1、2和3 mm的厚度（CMT1, CMT2, CMT3），最大厚度（CMTMAX）和根尖厚度（at = CMT1 - CMT2）。球面等效屈光不正是通过临床屈光来确定的。在控制受试者年龄的情况下，多因素回归分析评估CMT与屈光不正之间的关系。对26名受试者的图像进行分析，平均年龄（SD） 29岁；平均屈光误差（SD）：−0.90 (5.03)D，范围：−15.75至+5.13D)。平均（SD） CMT随后位而降低(CMT1: 804 (83) μm；CMT2: 543 (131) μm；CMT3: 312 (100) μm)。平均（SD） CMTMAX和AT分别为869 (57)μm和260 (84)μm。CMT1和CMT2随着年龄的增长，CMT变薄呈显著线性相关（p≤0.05）。CMT2与CMT3呈显著负相关（肌厚与近视屈光不正加重）（p≤0.01）。AT与肌肉增厚与远视屈光不正增加呈显著正相关（p <0.01）。研究发现，退行性椎体滑移患者的睫状肌厚度与之前报道的非退行性椎体滑移患者的屈光不正趋势范围相似。然而，值得注意的是，屈光不正的趋势是由中度到高度近视的个体驱动的。
The relationship between ciliary muscle thickness (CMT), age and refractive error was investigated to determine if CMT, like other anterior ocular anatomy, differs in adults with Down syndrome (DS). The CMT of 33 adults with DS was imaged using anterior segment optical coherence tomography. Images from the right eye obtained 45 minutes after cycloplegia (1% tropicamide, 2.5% phenylephrine) were analysed to calculate thickness at 1, 2 and 3 mm posterior to the scleral spur (CMT1, CMT2, CMT3), maximum thickness (CMTMAX) and apical thickness (AT = CMT1 – CMT2). Spherical equivalent refractive error was determined by clinical refraction using both non-dilated and dilated measures. Multivariate regression analysis evaluated the relationship between CMT and refractive error while controlling for subject age. Images were analysed from 26 subjects (mean age (SD) 29 years; mean refractive error (SD): −0.90 (5.03) D, range: −15.75 to +5.13D). Mean (SD) CMT decreased with posterior position (CMT1: 804 (83) μm; CMT2: 543 (131) μm; CMT3: 312 (100) μm). Mean (SD) CMTMAX and AT was 869 (57) μm and 260 (84) μm, respectively. There was a significant linear correlation indicating thinning CMT with increasing age for CMT1 and CMT2 (p ≤0.05). CMT2 and CMT3 had a significant negative correlation (thicker muscle with increasing myopic refractive error) (p ≤0.01). AT had a significant positive correlation (thicker muscle with increasing hyperopic refractive error) (p <0.01). Ciliary muscle thickness in participants with DS was found to be in a similar range with similar refractive error trends to previous reports of individuals without DS. However, it is important to note that the refractive error trends were driven by individuals with moderate to high levels of myopia.
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DOI：
10.1097/opx.0000000000001631
发表时间：
2021-01-01
期刊：
Optometry and vision science : official publication of the American Academy of Optometry
影响因子：
--
作者：
Anderson HA;Benoit JS;Marsack JD;Manny RE;Ravikumar A;Fern KD;Trast KR
通讯作者：
Trast KR
影响因子：
3.9
作者：
Muftuoglu, O.;Hosal, B. M.;Zilelioglu, G.
通讯作者：
Zilelioglu, G.
影响因子：
1.8
作者：
Wagner, Sandra;Zrenner, Eberhart;Strasser, Torsten
通讯作者：
Strasser, Torsten
影响因子：
13.7
作者：
Glasser, A;Kaufman, PL
通讯作者：
Kaufman, PL
影响因子：
4.4
作者：
Pucker, Andrew D.;Sinnott, Loraine T.;Bailey, Melissa D.
通讯作者：
Bailey, Melissa D.