Association of maternal neutrophil count in early pregnancy with the development of gestational diabetes mellitus: a prospective cohort study in China
Association of maternal neutrophil count in early pregnancy with the development of gestational diabetes mellitus: a prospective cohort study in China
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妊娠早期母体中性粒细胞计数与妊娠期糖尿病发生的关系：中国的一项前瞻性队列研究
DOI：
10.1080/09513590.2021.2025216
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发表时间：
2022-01
影响因子：
2
通讯作者：
Zhongxin Lu
中科院分区：
文献类型：
--
作者：
Man Kong;Hongmei Zhang;Xianchang Liu;Yanyan Ge;Zhen Zhang;Rui Zhao;Yan Li;Shanshan Huang;Guoping Xiong;Xuefeng Yang;Liping Hao;Zhongxin Lu
摘要 目的 我们评估妊娠早期母体血清中性粒细胞水平在预测妊娠期糖尿病 (GDM) 中的潜在作用。方法 这项前瞻性队列研究招募了妊娠第 16 周前的单胎孕妇，并对她们进行评估直至分娩。队列中 1467 名在妊娠 14 周前进行产前检查的孕妇中，共有 731 名符合最终分析条件。通过多变量逻辑回归评估中性粒细胞计数、白细胞计数、中性粒细胞与淋巴细胞比率和 GDM（通过 24 至 28 周之间的 75 g 口服葡萄糖耐量试验评估）之间的关联。结果 中性粒细胞计数在预测 GDM 发生方面优于中性粒细胞与淋巴细胞比率和白细胞计数。我们应用平滑函数，发现在调整孕前体重指数、糖尿病家族史和年龄后，中性粒细胞计数与空腹血糖 (FBG) (p=.0149) 和餐后 1 小时血糖 (PBG) (p=.0187) 相关。 Logistic回归分析发现，中性粒细胞计数最高水平（6.28–14.73 × 109/L）的GDM风险是最低三分位（1.47–4.82 × 109/L）的1.85倍（95% CI 1.10，3.09）。结论 结果表明较高的中性粒细胞水平与 GDM 的发生之间存在关联。
Abstract Objective We evaluated the potential role of maternal serum levels of neutrophils in the first trimester of pregnancy in the prediction of gestational diabetes mellitus (GDM). Methods This prospective cohort study enrolled singleton pregnant women before gestational weeks 16 and evaluated them until delivery. Among the 1467 pregnant women who performed prenatal care before 14 weeks of gestation in the cohort, a total of 731 were eligible for the final analysis. The associations between neutrophil counts, white blood cell count, neutrophil to lymphocyte ratio, and GDM (assessed by a 75-g oral glucose tolerance test between 24 and 28 weeks) were evaluated by multivariate logistic regression. Results Neutrophil count outperformed the neutrophil to lymphocyte ratio and white blood cell count in predicting GDM occurrence. We applied a smoothing function and found that neutrophil count was associated with both fasting blood glucose (FBG) (p=.0149) and 1-h postprandial blood glucose (PBG) (p=.0187) after adjustment pre-pregnancy body mass index, family history of diabetes, and age. Logistic regression analysis found that the highest neutrophil count level (6.28–14.73 × 109/L) had a 1.85-fold (95% CI 1.10, 3.09) increased risk of GDM compared with that of the lowest tertile (1.47–4.82 × 109/L). Conclusions The results indicated an association between higher neutrophil levels and GDM occurrence.
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DOI：
10.1084/jem.20122220
发表时间：
2013-07-01
期刊：
The Journal of experimental medicine
影响因子：
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作者：
Mócsai A
通讯作者：
Mócsai A
DOI：
10.1007/978-3-642-60639-7_3
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Yuan J
影响因子：
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通讯作者：
Olefsky, Jerrold M.
影响因子：
2
作者：
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通讯作者：
Yu, Qing