AMELIORATIVE EFFECTS OF HISTAMINE ON SPATIAL MEMORY DEFICITS INDUCED BY SCOPOLAMINE INFUSION INTO BILATERAL DORSAL OR VENTRAL HIPPOCAMPUS AS EVALUATED BY THE RADIAL ARM MAZE TASK
AMELIORATIVE EFFECTS OF HISTAMINE ON SPATIAL MEMORY DEFICITS INDUCED BY SCOPOLAMINE INFUSION INTO BILATERAL DORSAL OR VENTRAL HIPPOCAMPUS AS EVALUATED BY THE RADIAL ARM MAZE TASK
复制标题
通过桡臂迷宫任务评估组胺对双侧背侧或腹侧海马输注东莨菪碱引起的空间记忆缺陷的改善作用
DOI：
10.1111/j.1440-1681.2009.05157.x
复制
发表时间：
2009-08
影响因子：
2.9
通讯作者：
Chen, Zhong
中科院分区：
文献类型：
--
作者：
He, Ping;Fan, Yan-Ying;Hu, Wei-Wei;Xu, Li-Sha;Zhang, Wei-Ping;Chen, Zhong
1本研究采用放射状臂迷宫任务，观察了双侧海马背侧（DH）或腹侧（VH）注射东莨菪碱后海马组胺能系统对大鼠空间记忆障碍的调节作用。2双侧DH和VH注射东莨菪碱（5 μg/部位），在提取记忆过程中损害空间记忆。DH内注射组胺（50或100 ng/部位）和腹腔注射组氨酸（100 mg/kg）可明显改善DH内注射东莨菪碱引起的工作记忆和参考记忆障碍。组胺H1受体拮抗剂吡拉明（1 μg/部位）可消除组氨酸对工作记忆缺陷的改善作用，而吡拉明和H2受体拮抗剂西咪替丁（0.5 μg/部位）均可消除组氨酸对参考记忆的影响。3 VH内局部注射组胺（25或50 ng/位点）和全身注射组氨酸（50或100 mg/kg）可明显改善VH内注射东莨菪碱引起的工作记忆障碍，但对参考记忆障碍无改善作用。将吡拉明（0.2、0.5和1 µg/部位）和西咪替丁（0.1和0.5 µg/部位）注射到VH中可逆转组氨酸的作用。4本研究的结果表明，组胺对DH和VH中胆碱能相关记忆的作用不同。DH中的组胺通过作用于组胺H1受体改善空间工作记忆缺陷，并通过H1和H2受体改善参考记忆缺陷。然而，VH中的组胺通过作用于H1和H2受体来改善工作记忆缺陷。
1 The present study examined the role of the hippocampal histaminergic system in the regulation of spatial memory deficit in rats using the radial arm maze task after scopolamine injection into the bilateral dorsal (DH) or ventral (VH) hippocampus. 2 Bilateral injection of scopolamine (5 µg/site) into both the DH and VH impaired spatial memory in the retrieval memory process. Injection of histamine (50 or 100 ng/site) in the DH and intraperitoneal injection of histidine (100 mg/kg) markedly improved working memory and reference memory deficits induced by scopolamine injection into the DH. The histamine H1 receptor antagonist pyrilamine (1 µg/site) abolished the ameliorative effects of histidine on working memory deficits, whereas both pyrilamine and the H2 receptor antagonist cimetidine (0.5 µg/site) abolished the effect of histidine on reference memory. 3 Local injection of histamine (25 or 50 ng/site) into the VH and systemic injection of histidine (50 or 100 mg/kg) markedly improved working memory deficits induced by scopolamine injection into the VH, but did not improve the deficits in reference memory. Injection of both pyrilamine (0.2, 0.5 and 1 µg/site) and cimetidine (0.1 and 0.5 µg/site) into the VH reversed the effects of histidine. 4 The results of the present study indicate that histamine has different actions on cholinergic‐related memory in the the DH and VH. Histamine in the DH ameliorates spatial working memory deficits by acting on histamine H1 receptors and reference memory deficits through both H1 and H2 receptors. However, histamine in the VH ameliorates working memory deficits via an action on both H1 and H2 receptors.
登录
查看更多内容
影响因子：
--
作者：
C. Kamei;Z. Chen;S. Nakamura;Y. Sugimoto
通讯作者：
C. Kamei;Z. Chen;S. Nakamura;Y. Sugimoto
影响因子：
1.9
作者：
Olivier Potvin;K. Allen;Geneviève Thibaudeau;F. Doré;S. Goulet
通讯作者：
Olivier Potvin;K. Allen;Geneviève Thibaudeau;F. Doré;S. Goulet
影响因子：
2
作者：
P. Andersen;T. Bliss;K. Skrede
通讯作者：
P. Andersen;T. Bliss;K. Skrede
影响因子：
3.6
作者：
Chen, Z;Sugimoto, Y;Kamei, C
通讯作者：
Kamei, C
影响因子：
5.5
作者：
Brown, RE;Haas, HL
通讯作者：
Haas, HL