Anxiolytic Effect of Increased NREM Sleep after Acute Social Defeat Stress in Mice.
Anxiolytic Effect of Increased NREM Sleep after Acute Social Defeat Stress in Mice.
复制标题
小鼠急性社交失败压力后 NREM 睡眠增加的抗焦虑作用
DOI：
10.1007/s12264-020-00473-y
复制
发表时间：
2020-10
影响因子：
5.6
通讯作者：
Yu YQ
中科院分区：
文献类型：
--
作者：
Feng X;Zhao HY;Shao YJ;Lou HF;Zhu LY;Duan S;Yu YQ
社交失败应激（SDS）在焦虑和抑郁等精神疾病的发病机制中起着重要作用。睡眠通常被认为涉及在清醒期间从先前经历中恢复大脑，并且在急性SDS之后改变。然而，急性SDS对小鼠睡眠/觉醒行为的影响在研究之间存在差异。此外，睡眠是否因压力而改变，导致焦虑，还没有很好的确定。在这里，我们首先研究了急性SDS对小鼠活跃期睡眠/觉醒状态的影响。我们的研究结果表明，在急性SDS后的活跃期，总睡眠时间（快速眼动[REM]和非REM [NREM]睡眠时间）增加。NREM睡眠主要在SDS后的前3 h增加，而REM睡眠在以后增加。然后，我们证明了NREM睡眠的增加对急性SDS有抗焦虑作用。急性抑郁症后剥夺睡眠1h或3 h的小鼠仍处于高度焦虑状态，而自由睡眠的小鼠焦虑迅速消失。总之，我们的研究结果表明，NREM睡眠的抗焦虑作用，并指出一个潜在的治疗焦虑的策略。
Social defeat stress (SDS) plays a major role in the pathogenesis of psychiatric disorders like anxiety and depression. Sleep is generally considered to involve recovery of the brain from prior experience during wakefulness and is altered after acute SDS. However, the effect of acute SDS on sleep/wake behavior in mice varies between studies. In addition, whether sleep changes in response to stress contribute to anxiety is not well established. Here, we first investigated the effects of acute SDS on sleep/wake states in the active period in mice. Our results showed that total sleep time (time in rapid eye-movement [REM] and non-REM [NREM] sleep) increased in the active period after acute SDS. NREM sleep increased mainly during the first 3 h after SDS, while REM sleep increased at a later time. Then, we demonstrated that the increased NREM sleep had an anxiolytic benefit in acute SDS. Mice deprived of sleep for 1 h or 3 h after acute SDS remained in a highly anxious state, while in mice withad libitumsleep the anxiety rapidly faded away. Altogether, our findings suggest an anxiolytic effect of NREM sleep, and indicate a potential therapeutic strategy for anxiety.
登录
查看更多内容
通过短暂的慢波睡眠选择性诱导海马记忆巩固的关键时间窗口
影响因子：
5.6
作者：
Lu Y;Zhu ZG;Ma QQ;Su YT;Han Y;Wang X;Duan S;Yu YQ
通讯作者：
Yu YQ
影响因子：
25
作者：
Isingrini, Elsa;Perret, Lea;Giros, Bruno
通讯作者：
Giros, Bruno
影响因子：
3
作者：
Henderson F;Vialou V;El Mestikawy S;Fabre V
通讯作者：
Fabre V
影响因子：
2.9
作者：
Björkqvist, K
通讯作者：
Björkqvist, K
影响因子：
2.5
作者：
Meerlo, P;Pragt, BJ;Daan, S
通讯作者：
Daan, S