Haplotype-dependent HLA susceptibility to nasopharyngeal carcinoma in a Southern Chinese population.
Haplotype-dependent HLA susceptibility to nasopharyngeal carcinoma in a Southern Chinese population.
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DOI：
10.1038/gene.2009.109
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发表时间：
2010-06
影响因子：
5
通讯作者：
Gao, X.
中科院分区：
文献类型：
--
作者：
Tang, M.;Zeng, Y.;Poisson, A.;Marti, D.;Guan, L.;Zheng, Y.;Deng, H.;Liao, J.;Guo, X.;Sun, S.;Nelson, G.;de The, G.;Winkler, C. A.;O'Brien, S. J.;Carrington, M.;Gao, X.
我们对中国南方广西省的鼻咽癌（NPC）人群队列进行了一项全面的病例对照研究，广西是NPC发病率最高的地区之一。共有1407个人，包括NPC患者，健康对照，和他们的成年子女进行了检查的人类白细胞抗原（HLA）协会，这是迄今为止最大的NPC队列报告的此类研究。本研究中进行的分层分析清楚地表明，虽然NPC保护与独立的HLA等位基因相关，但大多数NPC易感性与HLA单倍型严格相关。我们的研究还首次发现，A*0206，一种南亚和东南亚独特的A2亚型，也与NPC的高风险相关。HLA-A*0206、HLA-B*3802等位基因与A*0207-B*4601、A*3303-B*5801单倍型的联合OR值为2.6（P<0.0001）。与鼻咽癌低风险相关的HLA等位基因包括HLA-A*1101、B*27和B*55，合并OR为0.42（P<0.0001）。广西人群中NPC易感HLA因子的总体高频率可能是该地区NPC高发的原因之一。
We have conducted a comprehensive case–control study of a nasopharyngeal carcinoma (NPC) population cohort from Guangxi Province of Southern China, a region with one of the highest NPC incidences on record. A total of 1407 individuals including NPC patients, healthy controls, and their adult children were examined for the human leukocyte antigen (HLA) association, which is so far the largest NPC cohort reported for such studies. Stratified analysis performed in this study clearly demonstrated that while NPC protection is associated with independent HLA alleles, most NPC susceptibility is strictly associated with HLA haplotypes. Our study also detected for the first time that A*0206, a unique A2 subtype to South and Southeast Asia is also associated with a high risk for NPC. HLA-A*0206, HLA-B*3802 alleles plus the A*0207–B*4601 and A*3303–B*5801 haplotypes conferred high risk for NPC showing a combined odds ratio (OR) of 2.6 (P<0.0001). HLA alleles that associate with low risk for NPC include HLA-A*1101, B*27, and B*55 with a combined OR of 0.42 (P<0.0001). The overall high frequency of NPC-susceptible HLA factors in the Guangxi population is likely to have contributed to the high-NPC incidence in this region.
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影响因子：
158.5
作者：
Gao, XJ;Nelson, GW;Carrington, M
通讯作者：
Carrington, M
影响因子：
6.4
作者：
YU, MC;HUANG, TB;HENDERSON, BE
通讯作者：
HENDERSON, BE
影响因子：
64.8
作者：
LU, SJ;DAY, NE;DETHE, G
通讯作者：
DETHE, G
影响因子：
6.4
作者：
Beyrer, C;Artenstein, AW;Natpratan, C
通讯作者：
Natpratan, C
DOI：
10.1002/hed.2880140307
发表时间：
1992-05-01
影响因子：
2.9
作者：
JOHANSEN, LV;MESTRE, M;OVERGAARD, J
通讯作者：
OVERGAARD, J