DHA supplementation: current implications in pregnancy and childhood.
DHA supplementation: current implications in pregnancy and childhood.
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DOI：
10.1016/j.phrs.2012.12.003
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发表时间：
2013-04
影响因子：
9.3
通讯作者：
Keim, Sarah A.
中科院分区：
文献类型：
--
作者：
Rogers, Lynette K.;Valentine, Christina J.;Keim, Sarah A.
近年来，饮食中补充（ω）-3长链脂肪酸（包括二十二碳六烯酸（DHA））越来越受欢迎，在妊娠期和幼儿期补充足够的DHA具有临床重要性。一些证据表明，在怀孕期间补充长链多不饱和脂肪酸（LCPUFA）如DHA对神经认知有好处;然而，最近的数据表明，抗炎特性可能至少具有同等重要性。胎儿/婴儿体内充足的DHA可通过影响神经递质通路来优化大脑和视网膜的成熟。LCPUFA的抗炎特性主要是通过直接通过与受体结合或通过改变脂筏形成和受体呈递来调节信号传导。我们的目标是回顾目前关于DHA补充剂的研究结果，特别是在怀孕和婴儿神经发育中，作为一种具有预防和治疗价值的药理剂。鉴于二十二碳六烯酸的总体益处，孕产妇和婴儿补充剂可能会改善神经系统结果，特别是在易受伤害的人群中。然而，补充剂的最佳组成和剂量以及治疗策略仍需要确定，以支持常规补充剂。
Dietary supplementation with (ω)-3 long chain fatty acids including docosahexaenoic acid (DHA) has increased in popularity in recent years and adequate DHA supplementation during pregnancy and early childhood is of clinical importance. Some evidence has been built for the neuro-cognitive benefits of supplementation with long chain polyunsaturated fatty acids (LCPUFA) such as DHA during pregnancy; however, recent data indicate that the anti-inflammatory properties may be of at least equal significance. Adequate DHA availability in the fetus/infant optimizes brain and retinal maturation in part by influencing neurotransmitter pathways. The anti-inflammatory properties of LCPUFA are largely mediated through modulation of signaling either directly through binding to receptors or through changes in lipid raft formation and receptor presentation. Our goal is to review the current findings on DHA supplementation, specifically in pregnancy and infant neurodevelopment, as a pharmacologic agent with both preventative and therapeutic value. Given the overall benefits of DHA, maternal and infant supplementation may improve neurological outcomes especially in vulernable populations. However, optimal composition of the supplement and dosing and treatment strategies still need to be determined to lend support for routine supplementation.
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DOI：
10.1016/j.plefa.2009.05.010
发表时间：
2009-08
期刊：
Prostaglandins, leukotrienes, and essential fatty acids
影响因子：
--
作者：
Chapkin RS;Kim W;Lupton JR;McMurray DN
通讯作者：
McMurray DN
营养中的Docosahexaenoic酸信号脂肪组学：衰老，神经炎症，黄斑变性，阿尔茨海默氏症和其他神经退行性疾病的重要性。
影响因子：
8.9
作者：
Bazan NG;Molina MF;Gordon WC
通讯作者：
Gordon WC
影响因子：
15.1
作者：
Bland, Sondra T.;Beckley, Jacob T.;Bilbo, Staci D.
通讯作者：
Bilbo, Staci D.
DOI：
10.1097/mpg.0b013e3181acae7d
发表时间：
2010-01-01
影响因子：
2.9
作者：
Beyerlein, Andreas;Hadders-Algra, Mijna;von Kries, Ruediger
通讯作者：
von Kries, Ruediger
影响因子：
3.6
作者：
Burdge, Graham C.;Powell, Jonathan;Calder, Philip C.
通讯作者：
Calder, Philip C.