Disrupted expected value signaling in youth with disruptive behavior disorders to environmental reinforcers.
Disrupted expected value signaling in youth with disruptive behavior disorders to environmental reinforcers.
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DOI：
10.1016/j.jaac.2013.12.023
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发表时间：
2014-05
影响因子：
13.3
通讯作者：
Blair, R. James
中科院分区：
文献类型：
--
作者：
White, Stuart F.;Fowler, Katherine A.;Sinclair, Stephen;Schechter, Julia C.;Majestic, Catherine M.;Pine, Daniel S.;Blair, R. James
具有破坏性行为障碍（DBD）的青年，包括行为障碍（CD）和对立违抗性障碍（ODD），在基于认知的决策中存在困难，其神经基础知之甚少。研究DBD青少年的决策过程发现，腹内侧前额叶皮层/眶额皮层（vmPFC/OFC）内的奖励反应减少，vmPFC和纹状体内对意外惩罚的反应增加，在避免次优选择的过程中，前额叶皮层和背侧前扣带皮层对预期价值信息的使用减少。以前的工作只使用货币加固。目前的研究检查了DBD青年在决策过程中的功能障碍是否扩展到环境保护者。共有30名青少年（15名健康青少年和15名DBD青少年）完成了一项新的学习模式，使用环境干扰器（物理威胁图像，例如，引人注目的蛇图像;污染威胁图像，例如，腐烂的食物;食欲图像，例如，幼犬）同时进行功能性磁共振成像（fMRI）。在行为上，健康的青年比DBD青年更容易避免身体威胁，但不是污染威胁，刺激。成像结果显示，青年DBD显示出显着减少使用的预期价值的信息，在双边尾状核，丘脑和后扣带皮层在避免次优反应。目前的数据表明，患有DBD的年轻人对环境保护者的赤字与对货币保护者的赤字相似。重要的是，这种缺陷与冷酷无情（CU）特征无关，这表明尾状核损伤可能是DBD青年的常见缺陷。
Youth with disruptive behavior disorders (DBD), including conduct disorder (CD) and oppositional defiant disorder (ODD), have difficulties in reinforcement-based decision making, the neural basis of which is poorly understood. Studies examining decision making in youth with DBD have revealed reduced reward responses within the ventrome-dial prefrontal cortex/orbitofrontal cortex (vmPFC/OFC), increased responses to unexpected punishment within the vmPFC and striatum, and reduced use of expected value information in the anterior insula cortex and dorsal anterior cingulate cortex during the avoidance of suboptimal choices. Previous work has used only monetary reinforcement. The current study examined whether dysfunction in youth with DBD during decision making extended to environmental reinforcers. A total of 30 youth (15 healthy youth and 15 youth with DBD) completed a novel reinforcement-learning paradigm using environmental reinforcers (physical threat images, e.g., striking snake image; contamination threat images, e.g., rotting food; appetitive images, e.g., puppies) while undergoing functional magnetic resonance imaging (fMRI). Behaviorally, healthy youth were significantly more likely to avoid physical threat, but not contamination threat, stimuli than youth with DBD. Imaging results revealed that youth with DBD showed significantly reduced use of expected value information in the bilateral caudate, thalamus, and posterior cingulate cortex during the avoidance of suboptimal responses. The current data suggest that youth with DBD show deficits to environmental reinforcers similar to the deficits seen to monetary reinforcers. Importantly, this deficit was unrelated to callous-unemotional (CU) traits, suggesting that caudate impairment may be a common deficit across youth with DBD.
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DOI：
10.1196/annals.1390.022
发表时间：
2007-01-01
期刊：
REWARD AND DECISION MAKING IN CORTICOBASAL GANGLIA NETWORKS
影响因子：
--
作者：
O'Doherty, John P.;Hampton, Alan;Kim, Hackjin
通讯作者：
Kim, Hackjin
影响因子：
3.6
作者：
Blair, RJR;Colledge, E;Mitchell, DGV
通讯作者：
Mitchell, DGV
影响因子：
4.6
作者：
Fergusson, David M.;Boden, Joseph M.;Horwood, L. John
通讯作者：
Horwood, L. John
影响因子：
17.7
作者：
Marsh, Abigail A.;Finger, Elizabeth C.;Blair, R. J. R.
通讯作者：
Blair, R. J. R.
影响因子：
2.3
作者：
Marsh, Abigail A.;Finger, Elizabeth C.;Fowler, Katherine A.;Jurkowitz, Ilana T. N.;Schechter, Julia C.;Yu, Henry H.;Pine, Daniel S.;Blair, R. J. R.
通讯作者：
Blair, R. J. R.