Yoga for cancer survivors with chemotherapy-induced peripheral neuropathy: Health-related quality of life outcomes.
Yoga for cancer survivors with chemotherapy-induced peripheral neuropathy: Health-related quality of life outcomes.
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DOI：
10.1002/cam4.4098
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发表时间：
2021-08
期刊：
影响因子：
4
通讯作者：
Bao T
中科院分区：
文献类型：
--
作者：
Zhi WI;Baser RE;Zhi LM;Talukder D;Li QS;Paul T;Patterson C;Piulson L;Seluzicki C;Galantino ML;Bao T
瑜伽是一种专注于身心意识的冥想运动疗法。瑜伽对化疗诱导的周围神经病变（CIPN）患者健康相关生活质量（HRQOL）结果的影响尚不清楚。我们对41名患有持续性中度至重度CIPN的乳腺癌和妇科癌症幸存者进行了一项8周瑜伽（n = 21）与等候名单对照（n = 20）的随机对照试验。HRQOL终点为医院焦虑抑郁量表（HADS）、短暂疲劳量表（BFI）和失眠严重程度指数（ISI）。治疗预期量表（TES）在基线进行。我们估计了从基线到第8周和第12周的平均变化和95%置信区间（ci），并使用约束线性混合模型比较各组。在第8周，瑜伽组的HADS焦虑评分下降了- 1.61分（- 2.75分，- 0.46分），等候名单对照组下降了- 0.32分（- 1.38分，0.75分）（p = 0.099）。在第12周，瑜伽组HADS焦虑评分下降了- 1.42(- 2.57,- 0.28)，而等候名单对照组增加了0.46 (- 0.60,1.53)（p = 0.017）。在瑜伽组和等候名单组之间，HADS抑郁、BFI或ISI评分没有显著差异。瑜伽组的基线TES显著高于等候名单对照组（14.9 vs. 12.7, p = 0.019）。TES与HADS焦虑减轻无关，HADS焦虑减轻与CIPN疼痛减轻无关。瑜伽可以减少CIPN患者的焦虑。需要进一步的研究来证实这些发现。临床试验注册号：ClinicalTrials.gov标识符：NCT03292328。瑜伽对化疗诱导的周围神经病变（CIPN）患者健康相关生活质量（HRQOL）结果的影响尚不清楚。我们对患有持续性中度至重度CIPN的乳腺癌和妇科癌症幸存者进行了一项为期8周的瑜伽和等待名单对照试验。我们的研究结果显示，与等候名单对照相比，在第8周和第12周，瑜伽有减少焦虑的趋势，但没有减少医院焦虑和抑郁量表抑郁评分、简短疲劳量表或失眠严重程度指数；需要进一步的研究来证实这些发现。
Yoga is a meditative movement therapy focused on mind‐body awareness. The impact of yoga on health‐related quality of life (HRQOL) outcomes in patients with chemotherapy‐induced peripheral neuropathy (CIPN) is unclear. We conducted a pilot randomized wait‐list controlled trial of 8 weeks of yoga (n = 21) versus wait‐list control (n = 20) for CIPN in 41 breast and gynecological cancer survivors with persistent moderate to severe CIPN. HRQOL endpoints were Hospital Anxiety and Depression Scale (HADS), Brief Fatigue Inventory (BFI), and Insomnia Severity Index (ISI). The Treatment Expectancy Scale (TES) was administered at baseline. We estimated mean changes and 95% confidence intervals (CIs) from baseline to weeks 8 and 12 and compared arms using constrained linear mixed models. At week 8, HADS anxiety scores decreased −1.61 (−2.75, −0.46) in the yoga arm and −0.32 (−1.38, 0.75) points in the wait‐list control arm (p = 0.099). At week 12, HADS anxiety scores decreased −1.42 (−2.57, −0.28) in yoga compared to an increase of 0.46 (−0.60, 1.53) in wait‐list control (p = 0.017). There were no significant differences in HADS depression, BFI, or ISI scores between yoga and wait‐list control. Baseline TES was significantly higher in yoga than in wait‐list control (14.9 vs. 12.7, p = 0.019). TES was not associated with HADS anxiety reduction and HADS anxiety reduction was not associated with CIPN pain reduction. Yoga may reduce anxiety in patients with CIPN. Future studies are needed to confirm these findings. Clinical Trial Registration Number: ClinicalTrials.gov Identifier: NCT03292328. The impact of yoga on health‐related quality of life (HRQOL) outcomes in patients with chemotherapy‐induced peripheral neuropathy (CIPN) is unclear. We conducted a pilot randomized wait‐list controlled trial of 8 weeks of yoga versus wait‐list control for CIPN in breast and gynecological cancer survivors with persistent moderate to severe CIPN. Our results showed a trend for yoga to decrease anxiety, but not Hospital Anxiety and Depression Scale depression scores, Brief Fatigue Inventory, or the Insomnia Severity Index, at weeks 8 and 12 compared to wait‐list control; future studies are needed to confirm these findings.
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影响因子：
3.1
作者：
Halappa NG;Thirthalli J;Varambally S;Rao M;Christopher R;Nanjundaiah GB
通讯作者：
Nanjundaiah GB
影响因子：
5.3
作者：
Calabrese F;Rossetti AC;Racagni G;Gass P;Riva MA;Molteni R
通讯作者：
Molteni R
影响因子：
2.4
作者：
Mao, Jun J.;Armstrong, Katrina;Bowman, Marjorie A.
通讯作者：
Bowman, Marjorie A.
影响因子：
2.6
作者：
Hong, J. S.;Tian, J.;Wu, L. H.
通讯作者：
Wu, L. H.
影响因子：
3.6
作者：
Cramer, Holger;Pokhrel, Bijay;Langhorst, Jost
通讯作者：
Langhorst, Jost