Exposure to polyfluoroalkyl chemicals and cholesterol, body weight, and insulin resistance in the general U.S. population.
Exposure to polyfluoroalkyl chemicals and cholesterol, body weight, and insulin resistance in the general U.S. population.
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DOI：
10.1289/ehp.0901165
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发表时间：
2010-02
影响因子：
10.4
通讯作者：
Webster TF
中科院分区：
文献类型：
--
作者：
Nelson JW;Hatch EE;Webster TF
多氟烷基化学品（pfc）广泛用于商业应用，在世界各地的人类和环境中都能检测到。人们担心它们可能会破坏脂质和体重调节。我们调查了PFC血清浓度与脂质和体重结果之间的关系。我们分析了2003-2004年全国健康和营养检查调查（NHANES）中12-80岁参与者的数据。利用线性回归控制协变量，我们研究了全氟辛酸（PFOA）、全氟壬酸（PFNA）、全氟辛烷磺酸（PFOS）和全氟己烷磺酸（PFHxS）的血清浓度与胆固醇、体型和胰岛素抵抗的关系。我们观察到PFOS、PFOA和PFNA浓度与总胆固醇和非高密度胆固醇呈正相关。我们发现PFHxS的情况正好相反。全氟辛烷磺酸暴露最高四分位数人群的总胆固醇水平为13.4 mg/dL[95%可信区间（CI）， 3.8-23.0]，高于最低四分位数人群。对于PFOA、PFNA和PFHxS，效应估计分别为9.8 （95% CI,−0.2至19.7）、13.9 （95% CI， 1.9至25.9）和−7.0 （95% CI,−13.2至−0.8）。当连续模拟暴露时，也出现了类似的模式。我们没有发现与体型或胰岛素抵抗有一致联系的证据。这项探索性横断面研究与其他流行病学研究一致，发现全氟辛烷磺酸和全氟辛烷磺酸与胆固醇之间存在正相关，尽管在NHANES中暴露量要低得多。PFNA和PFHxS的结果是新颖的，强调了研究PFOS和PFOA以外的PFCs的必要性。
Polyfluoroalkyl chemicals (PFCs) are used commonly in commercial applications and are detected in humans and the environment worldwide. Concern has been raised that they may disrupt lipid and weight regulation. We investigated the relationship between PFC serum concentrations and lipid and weight outcomes in a large publicly available data set. We analyzed data from the 2003–2004 National Health and Nutrition Examination Survey (NHANES) for participants 12–80 years of age. Using linear regression to control for covariates, we studied the association between serum concentrations of perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorooctane sulfonic acid (PFOS), and perfluorohexane sulfonic acid (PFHxS) and measures of cholesterol, body size, and insulin resistance. We observed a positive association between concentrations of PFOS, PFOA, and PFNA and total and non-high-density cholesterol. We found the opposite for PFHxS. Those in the highest quartile of PFOS exposure had total cholesterol levels 13.4 mg/dL [95% confidence interval (CI), 3.8–23.0] higher than those in the lowest quartile. For PFOA, PFNA, and PFHxS, effect estimates were 9.8 (95% CI, −0.2 to 19.7), 13.9 (95% CI, 1.9–25.9), and −7.0 (95% CI, −13.2 to −0.8), respectively. A similar pattern emerged when exposures were modeled continuously. We saw little evidence of a consistent association with body size or insulin resistance. This exploratory cross-sectional study is consistent with other epidemiologic studies in finding a positive association between PFOS and PFOA and cholesterol, despite much lower exposures in NHANES. Results for PFNA and PFHxS are novel, emphasizing the need to study PFCs other than PFOS and PFOA.
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影响因子：
16.2
作者：
Lin CY;Chen PC;Lin YC;Lin LY
通讯作者：
Lin LY
影响因子：
10.4
作者：
Calafat, Antonia M;Wong, Lee-Yang;Kuklenyik, Zsuzsanna;Reidy, John A;Needham, Larry L
通讯作者：
Needham, Larry L
影响因子：
4.1
作者：
Grün F;Blumberg B
通讯作者：
Blumberg B
DOI：
10.1097/01.jom.0000233380.13087.37
发表时间：
2006-08-01
影响因子：
3.2
作者：
Emmett, Edward Anthony;Zhang, Hong;Shaw, Leslie Michael
通讯作者：
Shaw, Leslie Michael
影响因子：
16.2
作者：
Bonora, E;Saggiani, F;Muggeo, M
通讯作者：
Muggeo, M