Hydroxylated PCB metabolites (OH-PCBs) in archived serum from 1950-60s California mothers: a pilot study.
Hydroxylated PCB metabolites (OH-PCBs) in archived serum from 1950-60s California mothers: a pilot study.
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DOI：
10.1016/j.envint.2009.04.002
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发表时间：
2009-08
影响因子：
11.8
通讯作者：
Factor-Litvak, P.
中科院分区：
文献类型：
--
作者：
Park, J. S.;Petreas, M.;Cohn, B. A.;Cirillo, P. M.;Factor-Litvak, P.
我们正在研究从儿童健康与发展研究(CHDS)中挑选的参与者，CHDS是1959至1967年间加州20,000多名孕妇的纵向出生队列，研究有机氯污染物的母亲身体负担与甲状腺功能之间的关系。我们设计了一项试点研究，从高和低多氯联苯浓度的样本中挑选了30个样本，以评估在更大的研究人群中测量羟基多氯联苯的可行性。用GC-ECD和GC-NCI/MS分别测定了多氯联苯和羟基多氯联苯的甲基衍生物。母体血清Σ11PCbs和Σ8OH-PCb代谢物水平分别为0.74~7.99 ng/m l湿重，中位数3.0 5 ng/m L和0.12~0.98 ng/m L湿重，中位数0.39 ng/m L。高Σ组的PCB8OH-PCb代谢物平均浓度显著高于低PCB组(p<；0.05)。羟基-多氯联苯代谢产物的水平取决于多氯联苯水平(r=0.58，p<；0.05)，但大约低一个数量级(p<；0.05)。Σ8OH-多氯联苯与Σ11多氯联苯的平均比值为0.14±0.08。主要代谢产物为4-羟基-CB187，其次为4-羟基-CB107。在体外、动物和人体研究中，这两种代谢物都会干扰甲状腺系统。在所有已分析的存档血清中均可检测到羟基多氯联苯，这支持了在整个队列中测量羟基多氯联苯代谢物的可行性。
We are studying participants selected from the Child Health and Development Studies (CHDS), a longitudinal birth cohort of over 20,000 California pregnancies between 1959 and 1967, for associations between maternal body burden of organochlorine contaminants and thyroid function. We designed a pilot study using 30 samples selected among samples with high and low PCB concentrations to evaluate the feasibility of measuring OH-PCBs in the larger study population. GC-ECD and GC-NCI/MS were used to determine PCBs and OH-PCBs as methyl derivatives, respectively. Maternal serum levels of Σ11PCBs and Σ8OH-PCB metabolites varied from 0.74 to 7.99 ng/mL wet wt. with a median of 3.05 ng/mL, and from 0.12 to 0.98 ng/mL wet wt. with a median of 0.39 ng/mL, respectively. Average concentrations of Σ8OH-PCB metabolites in the high PCB group were significantly higher than those in the low PCB group (p<0.05). The levels of OH-PCB metabolites were dependent on PCB levels (r=0.58, p<0.05) but approximately an order of magnitude lower (p<0.05). The average ratio of Σ8OH-PCBs to Σ11PCBs was 0.14±0.08. The primary metabolite was 4-OH-CB187 followed by 4-OH-CB107. Both of these metabolites interfere with the thyroid system in in vitro, animal, and human studies. OH-PCBs were detectable in all archived sera analyzed, supporting the feasibility to measure OH-PCB metabolites in the entire cohort.
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影响因子：
11.4
作者：
Fängström, B;Hovander, L;Bergmant, Å
通讯作者：
Bergmant, Å
DOI：
10.1073/pnas.0701944104
发表时间：
2007-05-01
影响因子：
11.1
作者：
Kenet, T.;Froemke, R. C.;Merzenich, M. M.
通讯作者：
Merzenich, M. M.
影响因子：
8.8
作者：
Norén, K;Meironyté, D
通讯作者：
Meironyté, D
影响因子：
10.4
作者：
Fängström, B;Athanasiadou, M;Bergman, Å
通讯作者：
Bergman, Å
影响因子：
1.8
作者：
Malmberg, T;Hoogstraate, J;Wehler, EK
通讯作者：
Wehler, EK