Gd-based Contrast Enhancement of the Perivascular Spaces in the Basal Ganglia.
Gd-based Contrast Enhancement of the Perivascular Spaces in the Basal Ganglia.
复制标题
DOI：
10.2463/mrms.mp.2016-0039
复制
发表时间：
2017-01-10
期刊：
影响因子：
--
通讯作者：
Taoka T
中科院分区：
文献类型：
--
作者：
Naganawa S;Nakane T;Kawai H;Taoka T
在教科书中，血管周围间隙（PVS）被描述为静脉注射钆基造影剂（IV-GBCA）后无增强。我们注意到IV-GBCA后4小时获得的重T2加权3D-FLAIR（hT 2-FL）图像上PVS有时具有高信号强度（SI）。本研究的目的是回顾性评价PVS的对比增强。 在8名健康受试者和19名疑似内淋巴积水患者中，在单剂量IV-GBCA之前和之后4小时获得磁共振脑池造影（MRC）和hT 2-FL图像。无受试者发生肾功能不全。在前连合（AC）-后连合（PC）线水平的轴向MRC上，以双侧基底节和丘脑中的PVS为中心绘制1 cm圆形感兴趣区域（ROI）。在双侧环池的脑脊液（CSF）中设置直径为3 mm的ROI。将MRC上的ROI复制到hT 2-FL图像上，并测量SI。SI比值（SIR）定义为SIRPVS = PVS的SI/丘脑的SI，SIRCSF = CSF的SI/丘脑的SI。双侧值的平均值用于计算。比较IV-GBCA前后丘脑SIRCSF、SIRPVS和SI的变化。IV-GBCA后4 h，CSF中SIR由1.02 ± 0.37增至2.65 ± 0.82（P < 0.01），PVS中SIR由1.20 ± 0.35增至2.13 ± 1.23（P < 0.01）。丘脑的SI无显著性差异。IV-GBCA后4小时PVS的增强即使在无肾功能不全的受试者中也得到证实。血管中的GBCA可能已渗透到脑脊液（CSF）间隙和PVS中。这可能是大脑胶质淋巴系统（废物清除系统）成像评估的第一步。
In textbooks, the perivascular space (PVS) is described as non-enhancing after the intravenous administration of gadolinium-based contrast agent (IV-GBCA). We noticed that the PVS sometimes has high signal intensity (SI) on heavily T2-weighted 3D-FLAIR (hT2-FL) images obtained 4 h after IV-GBCA. The purpose of this study was to retrospectively evaluate the contrast enhancement of the PVS. In 8 healthy subjects and 19 patients with suspected endolymphatic hydrops, magnetic resonance cisternography (MRC) and hT2-FL images were obtained before and 4 h after a single dose of IV-GBCA. No subjects had renal insufficiency. On axial MRC at the level of the anterior commissure (AC)-posterior commissure (PC) line, 1 cm circular regions of interest (ROIs) were drawn centering on the PVS in the bilateral basal ganglia and thalami. Three-millimeter diameter ROIs were set in the cerebrospinal fluid (CSF) of the bilateral ambient cistern. The ROIs on MRC were copied onto the hT2-FL images and the SI was measured. The SI ratio (SIR) was defined as SIRPVS = SI of PVS/SI of the thalami, and SIRCSF = SI of CSF/SI of the thalami. The average of the bilateral values was used for the calculation. The SIRCSF, SIRPVS, and SI of the thalami were compared between before and 4 h after IV-GBCA. The SIR was increased significantly from 1.02 ± 0.37 to 2.65 ± 0.82 in the CSF (P < 0.01) and from 1.20 ± 0.35 to 2.13 ± 1.23 in the PVS at 4 h after IV-GBCA (P < 0.01). The SI of the thalami showed no significant difference. The enhancement of the PVS at 4 h after IV-GBCA was confirmed even in subjects without renal insufficiency. It is possible that the GBCA in the blood vessels might have permeated into the cerebrospinal fluid (CSF) space and the PVS. This might be a first step in the imaging evaluation of the glymphatic system (waste clearance system) of the brain.
登录
查看更多内容
影响因子：
3
作者：
Naganawa, Shinji;Kawai, Hisashi;Nakashima, Tsutomu
通讯作者：
Nakashima, Tsutomu
影响因子：
4
作者：
Bakker EN;Bacskai BJ;Arbel-Ornath M;Aldea R;Bedussi B;Morris AW;Weller RO;Carare RO
通讯作者：
Carare RO
影响因子：
4.4
作者：
Jessen NA;Munk AS;Lundgaard I;Nedergaard M
通讯作者：
Nedergaard M
影响因子：
3
作者：
Naganawa, Shinji;Suzuki, Kojiro;Sakurai, Yasuo
通讯作者：
Sakurai, Yasuo
影响因子：
3
作者：
Naganawa, Shinji;Yamazaki, Masahiro;Nakashima, Tsutomu
通讯作者：
Nakashima, Tsutomu