Tissue-level remodeling simulations of cancellous bone capture effects of in vivo loading in a rabbit model.
Tissue-level remodeling simulations of cancellous bone capture effects of in vivo loading in a rabbit model.
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DOI：
10.1016/j.jbiomech.2014.12.011
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发表时间：
2015-03-18
影响因子：
2.4
通讯作者：
van der Meulen, Marjolein C. H.
中科院分区：
文献类型：
--
作者：
Morgan, Timothy G.;Bostrom, Mathias P. G.;van der Meulen, Marjolein C. H.
松质骨对机械刺激的适应发生在整个骨骼的正常生长和老化过程中，以及对手术、疾病和装置植入的反应。在此之前，我们在兔股骨远端外侧建立了体内松质骨负荷模型。在连续四周的每日体内负荷下，骨量增加，骨小梁增厚，松质骨的表观模数增加。在这里，我们使用一种基于细胞的组织重塑算法模拟了我们先前的活体兔负荷实验，并将结果与先前发表的体内实验数据进行了比较。在高机械刺激和低机械刺激区域分别添加或去除骨小梁表面的松质骨组织。为了检验材料特性对机械调节适应性的影响，我们实现了一个均匀材料模型和一个模型，其中新生骨组织和表面骨组织的相对密度比内部组织低。这些模拟捕捉到了在活体实验中测量的组织形态计量学参数和力学性能的变化，说明了计算模拟的能力，以预测机械调节适应对松质骨组织形态计量学和表观弹性系数的影响。
The adaptation of cancellous bone to mechanical stimuli occurs throughout normal skeletal growth and aging, as well as in response to surgery, disease and device implantation. Previously we developed an in vivo cancellous loading model in the distal lateral femur of the rabbit. In response to daily in vivo loading for four weeks, bone mass increased, trabeculae thickened and the apparent modulus of the underlying cancellous bone increased. Here, we simulated our prior in vivo rabbit loading experiment using a cell-based tissue remodeling algorithm and compared the results to the in vivo experimental data published previously. Cancellous bone tissue was added or removed from the surface of trabeculae in regions of high and low mechanical stimulus, respectively. To examine the effect of material properties on mechanically regulated adaptation, we implemented both a homogeneous material model and a model where the relative density of tissue was lower for new and surface bone tissue compared to interior tissue. The simulations captured the changes in histomorphometric parameters and mechanical properties measured in the in vivo experiment illustrating the ability of computational simulations to predict the effect of mechanically regulated adaptation on cancellous bone histomorphometry and apparent modulus.
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影响因子：
2.8
作者：
MULLENDER, MG;HUISKES, R
通讯作者：
HUISKES, R
影响因子：
4.1
作者：
Lambers, Floor M.;Schulte, Friederike A.;Mueller, Ralph
通讯作者：
Mueller, Ralph
影响因子：
2.8
作者：
BEAUPRE, GS;ORR, TE;CARTER, DR
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CARTER, DR
影响因子：
2.4
作者：
GOULET, RW;GOLDSTEIN, SA;FELDKAMP, LA
通讯作者：
FELDKAMP, LA
影响因子：
4.2
作者：
Paschalis, EP;Betts, F;Boskey, AL
通讯作者：
Boskey, AL