Alcohol consumption, finasteride, and prostate cancer risk: results from the Prostate Cancer Prevention Trial.
Alcohol consumption, finasteride, and prostate cancer risk: results from the Prostate Cancer Prevention Trial.
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DOI：
10.1002/cncr.24423
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发表时间：
2009-08-15
期刊：
影响因子：
6.2
通讯作者：
Thompson IM
中科院分区：
文献类型：
--
作者：
Gong Z;Kristal AR;Schenk JM;Tangen CM;Goodman PJ;Thompson IM
目前的研究是关于饮酒和前列腺癌风险之间的关系没有定论。我们研究了总酒精、酒精饮料类型和饮酒模式与总前列腺癌、低级别前列腺癌和高级别前列腺癌风险的关系。数据来自前列腺癌预防试验（PCPT）的2，129名参与者，他们在7年的试验期间检测到癌症，8，791人在试验结束时通过活检确定没有癌症。Poisson回归用于计算酒精摄入与前列腺癌风险相关的相对风险（RR）和95%置信区间（CI）。饮酒与高级别疾病的相关性在治疗组之间没有差异。（≥50 g酒精/天）和经常大量饮酒（每周≥5天，每天饮酒≥4次）与高级别前列腺癌风险增加相关（RR：2.01，95%CI：1.33-3.05和2.17，95%CI：1.42 - 3.30）;少量饮酒与风险无关。饮酒与低度癌症的关联在不同的治疗组中有所不同。在安慰剂组中，饮酒与低度癌症的风险没有关联。在芬氟拉明组中，每天饮酒≥50 g与轻度疾病风险增加相关（RR：1.89，95% CI：1.39-2.56）;这一发现是由于每天饮酒<50 g的男性中，使用非那肽治疗后，低度癌症风险降低了43%，而在饮酒≥50 g的男性中，非那肽没有效果。（P相互作用=0.03）。每天大量饮酒会增加患高级前列腺癌的风险。大量饮酒使芬达对降低前列腺癌风险无效。
Current research is inconclusive regarding the relationship between alcohol consumption and prostate cancer risk. We examined the associations of total alcohol, type of alcoholic beverage, and drinking pattern with risks of total, low- and high-grade prostate cancer. Data are from the 2,129 participants in the Prostate Cancer Prevention Trial (PCPT) who had cancer detected during the 7-year trial and 8,791 who were determined by biopsy to be free of cancer at the trial end. Poisson regression was used to calculate relative risks (RRs) and 95% confidence intervals (CIs) for associations of alcohol intake with prostate cancer risk. Associations of drinking with high-grade disease did not differ by treatment arm. In combined arms, heavy alcohol consumption (≥50 g alcohol/day) and regular heavy drinking (≥4 drinks/day on ≥5 days per week) were associated with increased risks of high-grade prostate cancer (RR: 2.01, 95% CI: 1.33-3.05 and 2.17, 95% CI: 1.42 -3.30, respectively); less heavy drinking was not associated with risk. Associations of drinking with low-grade cancer differed by treatment arm. In the placebo arm, there was no association of drinking with risk of low-grade cancer. In the finasteride arm, drinking ≥50 g of alcohol/day was associated an increased risk of low-grade disease (RR: 1.89, 95% CI: 1.39-2.56); this finding was due to the 43% reduction in risk of low-grade cancer attributable to finasteride treatment in men drinking <50g alcohol per day and the lack of an effect of finasteride in men drinking ≥50 g of alcohol/day per day (Pinteraction=0.03). Heavy, daily drinking increases the risk of high-grade prostate cancer. Heavy drinking made finasteride ineffective for reducing prostate cancer risk.
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影响因子：
2.3
作者：
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通讯作者：
Wallace, RB
影响因子：
2.3
作者：
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LONGNECKER, MP
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作者：
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通讯作者：
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作者：
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通讯作者：
Ronco, A