Sys-BodyFluid: a systematical database for human body fluid proteome research.

Sys-BodyFluid: a systematical database for human body fluid proteome research.
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DOI:
10.1093/nar/gkn849
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发表时间:
2009-01
影响因子:
14.9
通讯作者:
Zeng R
Zeng R
中科院分区:
生物学2区
文献类型:
--
作者:
Li SJ;Peng M;Li H;Liu BS;Wang C;Wu JR;Li YX;Zeng R

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近年来,体液已成为蛋白质组学研究的重要对象,蛋白质组学研究产生了越来越多与体液相关的蛋白质数据。需要一个数据库来收集和分析这些蛋白质组数据。因此,我们开发了这个基于Web的体液蛋白质组数据库Sys-BodyFluid。它包含11种体液蛋白质组,包括血浆/血清、尿液、脑脊液、唾液、支气管肺泡灌洗液、滑液、乳头抽吸液、泪液、精液、人乳和羊水。超过10000种蛋白质存在于系统体液中。Sys-BodyFluid提供了详细的蛋白质注释,包括蛋白质描述、基因本体、结构域信息、蛋白质序列和相关通路。这些蛋白质组数据可以通过蛋白质名称、蛋白质登录号和序列相似性进行检索。此外,用户可以在这些不同的体液之间进行查询,以获得不同的蛋白质识别信息。Sys-BodyFluid数据库可作为体液蛋白质组学和疾病蛋白质组学研究的参考数据库。可在http://www.biosino.org/bodyfluid/上查阅。
Recently, body fluids have widely become an important target for proteomic research and proteomic study has produced more and more body fluid related protein data. A database is needed to collect and analyze these proteome data. Thus, we developed this web-based body fluid proteome database Sys-BodyFluid. It contains eleven kinds of body fluid proteomes, including plasma/serum, urine, cerebrospinal fluid, saliva, bronchoalveolar lavage fluid, synovial fluid, nipple aspirate fluid, tear fluid, seminal fluid, human milk and amniotic fluid. Over 10 000 proteins are presented in the Sys-BodyFluid. Sys-BodyFluid provides the detailed protein annotations, including protein description, Gene Ontology, domain information, protein sequence and involved pathways. These proteome data can be retrieved by using protein name, protein accession number and sequence similarity. In addition, users can query between these different body fluids to get the different proteins identification information. Sys-BodyFluid database can facilitate the body fluid proteomics and disease proteomics research as a reference database. It is available at http://www.biosino.org/bodyfluid/.
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