STARD13-correlated ceRNA network inhibits EMT and metastasis of breast cancer.
STARD13-correlated ceRNA network inhibits EMT and metastasis of breast cancer.
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STARD13相关的ceRNA网络抑制乳腺癌的EMT和转移
DOI：
10.18632/oncotarget.8099
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发表时间：
2016-04-26
期刊：
影响因子：
--
通讯作者：
Xi T
中科院分区：
文献类型：
--
作者：
Li X;Zheng L;Zhang F;Hu J;Chou J;Liu Y;Xing Y;Xi T
Competing endogenous RNAs (ceRNAs) network has been correlated with the initiation and development of cancer. Here, we identify CDH5, HOXD1, and HOXD10 as putative STARD13 ceRNAs and they display concordant patterns with STARD13 in different metastatic potential breast cancer cell lines and tissues. Notably, 3’UTRs of these genes suppress breast cancer metastasis via inhibiting epithelial-mesenchymal transition (EMT) in vitro and in vivo, which are activated through the crosstalk between STARD13 and its ceRNAs in 3’UTR- and miRNA-dependent manners. In addition, Kaplan-Meier survival analysis reveals that mRNA level of STARD13 and its ceRNAs is remarkably associated with survival of breast cancer patients. These results suggest that 3’UTRs of CDH5, HOXD1, and HOXD10 inhibit breast cancer metastasis via serving as STARD13 ceRNAs.
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影响因子：
14.9
作者：
Mercer TR;Wilhelm D;Dinger ME;Soldà G;Korbie DJ;Glazov EA;Truong V;Schwenke M;Simons C;Matthaei KI;Saint R;Koopman P;Mattick JS
通讯作者：
Mattick JS
影响因子：
46.9
作者：
Ma L;Reinhardt F;Pan E;Soutschek J;Bhat B;Marcusson EG;Teruya-Feldstein J;Bell GW;Weinberg RA
通讯作者：
Weinberg RA
影响因子：
28.2
作者：
Karreth FA;Pandolfi PP
通讯作者：
Pandolfi PP
通过未翻译基因区域和其他非编码元件调节真核基因表达。
影响因子：
8
作者：
Barrett, Lucy W.;Fletcher, Sue;Wilton, Steve D.
通讯作者：
Wilton, Steve D.
影响因子：
8
作者：
Gómez-Maldonado L;Tiana M;Roche O;Prado-Cabrero A;Jensen L;Fernandez-Barral A;Guijarro-Muñoz I;Favaro E;Moreno-Bueno G;Sanz L;Aragones J;Harris A;Volpert O;Jimenez B;del Peso L
通讯作者：
del Peso L