Microstructural abnormalities in language and limbic pathways in orphanage-reared children: a diffusion tensor imaging study.
Microstructural abnormalities in language and limbic pathways in orphanage-reared children: a diffusion tensor imaging study.
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DOI：
10.1177/0883073812474098
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发表时间：
2014-03
影响因子：
1.9
通讯作者：
Chugani HT
中科院分区：
文献类型：
--
作者：
Kumar A;Behen ME;Singsoonsud P;Veenstra AL;Wolfe-Christensen C;Helder E;Chugani HT
这项研究利用扩散张量成像纤维束成像技术检测了36名儿童(平均年龄为124个月)边缘和边缘旁白质束的微结构完整性，这些儿童有早期剥夺史，在孤儿院长大，后来被收养到美国，与16名年龄匹配的典型发育中的儿童进行了比较。我们发现早期剥夺儿童双侧弓状束的平均弥散系数增加，双侧钩带束和扣带的平均弥散系数增加，分数各向异性降低。左侧弓状束和右侧扣带的微结构完整性分别与语言和行为功能有关。白质异常也与剥夺时间和在领养家庭的时间有关。我们的发现表明，在有早期剥夺史的儿童中，连接边缘和边缘旁大脑区域的白质通路是异常的；其中一些通路似乎比其他通路更容易受到早期剥夺的影响。
This study utilized diffusion tensor imaging fiber tractography to examine the miscrostructural integrity of limbic and paralimbic white matter tracts in thirty-six children (Mean age=124 months) with histories of early deprivation, raised from birth in orphanages and subsequently adopted into the United States, compared to 16 age-matched typically developing children. We found increased mean diffusivity bilaterally in the arcuate fasciculus, and increased mean diffusivity and reduced fractional anisotropy bilaterally in the uncinate fasciculus and cingulum in children with early deprivation. Microstructural integrity of the left arcuate fasciculus and right cingulum was related to language and behavioral functioning, respectively. White matter abnormalities were also associated with length of deprivation and time in the adoptive home. Our findings suggest that white matter pathways, connecting limbic and paralimbic brain regions is abnormal in children with histories of early deprivation; with some pathways appearing more susceptible to early deprivation than others.
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