White matter microstructure abnormalities and executive function in adolescents with prenatal cocaine exposure.
White matter microstructure abnormalities and executive function in adolescents with prenatal cocaine exposure.
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DOI：
10.1016/j.pscychresns.2013.04.002
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发表时间：
2013-08-30
影响因子：
11.3
通讯作者：
Sowell ER
中科院分区：
文献类型：
--
作者：
Lebel C;Warner T;Colby J;Soderberg L;Roussotte F;Behnke M;Davis Eyler F;Sowell ER
出生前接触可卡因的儿童有较高的负性行为功能和注意力困难的风险，并表现出额叶白质区域的脑扩散异常。然而，还没有使用弥散张量成像(DTI)来研究额叶和胼胝体以外的脑区。收集了42名14-16岁青年的DTI数据；根据详细的暴露历史将受试者分为三组：产前暴露于可卡因而不是酒精的组(PCE，n=12)，产前暴露于可卡因和酒精的组(CAE，n=17)，以及对照组(n=13)。进行了声道造影术，并检查了沿道弥散参数的组间差异和与执行功能测量的相关性。在右侧弓状束和扣带，CAE组的分数各向异性(FA)和/或平均弥散系数(MD)均高于其他两组。与对照组相比，PCE组右侧穹隆状核的FA降低，而压部的MD升高。有组间差异的脑束弥散参数与执行功能的测量相关。总而言之，出生前接触可卡因的青少年的这些扩散差异表明，局部的、长期的脑部结构性改变可能是注意力和反应抑制困难的基础。
Children with prenatal exposure to cocaine are at higher risk for negative behavioral function and attention difficulties, and have demonstrated brain diffusion abnormalities in frontal white matter regions. However, brain regions beyond frontal and callosal areas have not been investigated using diffusion tensor imaging (DTI). DTI data were collected on 42 youth aged 14–16 years; subjects were divided into three groups based on detailed exposure histories: those with prenatal exposure to cocaine but not alcohol (PCE, n=12), prenatal exposure to cocaine and alcohol (CAE, n=17), and controls (n=13). Tractography was performed and along-tract diffusion parameters were examined for group differences and correlations with executive function measures. In the right arcuate fasciculus and cingulum, the CAE group had higher fractional anisotropy (FA) and/or lower mean diffusivity (MD) than the other two groups. The PCE group demonstrated lower FA in the right arcuate and higher MD in the splenium of the corpus callosum than controls. Diffusion parameters in tracts with group differences correlated with measures of executive function. In conclusion, these diffusion differences in adolescents with prenatal cocaine exposure suggest localized, long-term structural brain alterations that may underlie attention and response inhibition difficulties.
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作者：
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DOI：
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发表时间：
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影响因子：
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