Tissue properties and respiratory kinematics of the tongue base and soft palate in the obese OSA minipig.
Tissue properties and respiratory kinematics of the tongue base and soft palate in the obese OSA minipig.
复制标题
DOI：
10.1371/journal.pone.0293907
复制
发表时间：
2023
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
肥胖是成人阻塞性睡眠呼吸暂停（OSA）的常见发现和主要致病因素。为了了解这背后的机制，本研究调查了肥胖OSA小型猪模型的舌根和软腭的组织特性和呼吸运动学。在4只肥胖/OSA和3只非肥胖/非OSA对照小型猪中，进行MRI脂肪加权图像、超声弹性成像（USE）和睡眠视频荧光透视（SVF），以量化镇静睡眠期间舌根和软腭的脂肪组成、组织硬度和呼吸运动学。结果表明，无论是否肥胖或阻塞性睡眠呼吸暂停综合征，舌根的脂肪组成从舌根的吻侧到舌根的尾侧逐渐增加，尤其是舌根的后1/3。然而，这种趋势在软腭和咽壁中未见。咽壁的脂肪含量最高，其次是舌根和软腭。总的来说，肥胖OSA小型猪显示出比对照组更硬的舌组织，特别是在肥胖尤卡坦小型猪的舌的喙部区域。OSA肥胖小型猪软腭的呼吸运动范围在背腹和头尾两个方向上以及在呼吸和呼气相均大于对照小型猪，并且在OSA肥胖Panepinto小型猪中观察到最大的运动范围。舌根活动范围明显缩小。这些结果表明，无论是否存在肥胖和/或OSA，舌根尾部区域的脂肪浸润更多。肥胖OSA小型猪舌头组织硬度的增加可能是由于神经肌肉驱动的改变。
Obesity is a common finding and a major pathogenetic factor in obstructive sleep apnea (OSA) in adults. To understand the mechanisms behind this, the present study investigated the tissue properties and respiratory kinematics of the tongue base and soft palate in the obese OSA minipig model. In 4 verified obese/OSA and 3 non-obese/non-OSA control minipigs, MRI fat-weighted images, ultrasound elastography (USE), and sleep video-fluoroscopy (SVF) were performed to quantify the fat composition, tissue stiffness, and respiratory kinematics of the tongue base and soft palate during sedated sleep. The results indicated that the fat composition gradually increased from the rostral to caudal tongue base, particularly in the posterior 1/3 of the tongue base, regardless of the presence of obesity and OSA. However, this trend was not seen in the soft palate and pharyngeal wall. The pharyngeal wall presented the highest fat composition as compared with the tongue base and soft palate. Overall, obese OSA minipigs showed stiffer tongue tissue than the controls, particularly in the rostral region of the tongue in obese Yucatan minipigs. The respiratory moving ranges of the soft palate were greater in both dorsal-ventral and rostral-caudal directions and during both respiratory and expiratory phases in OSA obese than control minipigs, and the largest moving ranges were seen in OSA obese Panepinto minipigs. The moving range of the tongue base was significantly smaller. These results suggest more fat infiltration in the caudal region of the tongue base regardless of the presence of obesity and/or OSA. The greater tissue stiffness of the tongue in obese OSA minipigs may result from altered neuromuscular drive.
登录
查看更多内容
影响因子：
2.9
作者：
Leotta DF;Bruce M;Wang YN;Kucewicz J;Khokhlova T;Chan K;Monsky W;Matula TJ
通讯作者：
Matula TJ
影响因子：
2
作者：
Nakajima, Ikuyo;Oe, Mika;Chikuni, Koichi
通讯作者：
Chikuni, Koichi
影响因子：
2.9
作者：
Chang, Chun-Hsiang;Huang, Chih-Chung;Chen, Jeng-Wen
通讯作者：
Chen, Jeng-Wen
影响因子：
2.6
作者：
Nakao, Yuta;Yamashita, Taiji;Domen, Kazuhisa
通讯作者：
Domen, Kazuhisa
影响因子：
1.4
作者：
Kim, Jeong-Whun;Yoon, In Young;Yun, Pil Young
通讯作者：
Yun, Pil Young