Mass spectrometric strategies for the investigation of biomarkers of illicit drug use in wastewater.
Mass spectrometric strategies for the investigation of biomarkers of illicit drug use in wastewater.
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DOI：
10.1002/mas.21525
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发表时间：
2018-05
影响因子：
6.6
通讯作者：
Bijlsma L
中科院分区：
文献类型：
--
作者：
Hernández F;Castiglioni S;Covaci A;de Voogt P;Emke E;Kasprzyk-Hordern B;Ort C;Reid M;Sancho JV;Thomas KV;van Nuijs ALN;Zuccato E;Bijlsma L
对城市废水中非法药物的分析是基于废水的流行病学（WBE）的基础，并受到了科学界的广泛关注，因为测量的浓度可以用作一种新的非侵入性工具，以提供基于证据的真实的时间估计社区范围内的药物消费。此外，WBE允许监测毒品使用的模式和时空趋势。虽然需要来自其他学科的信息和专业知识来完善和有效地应用WBE，但分析化学是该领域的基本驱动力。使用先进的分析技术，通常是基于色谱-质谱联用，是强制性的，因为分析物浓度很低，样品（原废水）的复杂性使得非法药物生物标志物的定量和鉴定/确认很麻烦。我们回顾了有关废水中IDB测定的最新文献（大部分来自过去5年），特别强调所应用的不同分析策略。说明了液相色谱-串联质谱法在定量目标IDBs方面的优势以及产生可靠和可比结果的本质。因此，强调了进行实验室间练习的重要性以及分析每个样品序列中适当质控品的必要性。WBE中的其他关键步骤，如样品收集和样品预处理，都进行了简要和仔细的讨论。本文进一步关注高分辨率质谱的潜力。讨论了目标和非目标分析的不同方法，以及在实验室控制条件下进行实验的兴趣，作为研究相关化合物的补充工具（例如，废水中的次要代谢物和/或转化产物）进行处理。文章最后从作者的角度提出了该领域的发展趋势和前景。© 2016作者。Wiley Periodicals，Inc.质量标准修订版37：258-280，2018
The analysis of illicit drugs in urban wastewater is the basis of wastewater‐based epidemiology (WBE), and has received much scientific attention because the concentrations measured can be used as a new non‐intrusive tool to provide evidence‐based and real‐time estimates of community‐wide drug consumption. Moreover, WBE allows monitoring patterns and spatial and temporal trends of drug use. Although information and expertise from other disciplines is required to refine and effectively apply WBE, analytical chemistry is the fundamental driver in this field. The use of advanced analytical techniques, commonly based on combined chromatography—mass spectrometry, is mandatory because the very low analyte concentration and the complexity of samples (raw wastewater) make quantification and identification/confirmation of illicit drug biomarkers (IDBs) troublesome. We review the most‐recent literature available (mostly from the last 5 years) on the determination of IDBs in wastewater with particular emphasis on the different analytical strategies applied. The predominance of liquid chromatography coupled to tandem mass spectrometry to quantify target IDBs and the essence to produce reliable and comparable results is illustrated. Accordingly, the importance to perform inter‐laboratory exercises and the need to analyze appropriate quality controls in each sample sequence is highlighted. Other crucial steps in WBE, such as sample collection and sample pre‐treatment, are briefly and carefully discussed. The article further focuses on the potential of high‐resolution mass spectrometry. Different approaches for target and non‐target analysis are discussed, and the interest to perform experiments under laboratory‐controlled conditions, as a complementary tool to investigate related compounds (e.g., minor metabolites and/or transformation products in wastewater) is treated. The article ends up with the trends and future perspectives in this field from the authors’ point of view. © 2016 by The Authors. Mass Spectrometry Reviews published by Wiley Periodicals, Inc. Mass Spec Rev 37:258–280, 2018
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影响因子：
4.3
作者：
Bade, Richard;Rousis, Nikolaos I.;Hernandez, Felix
通讯作者：
Hernandez, Felix
影响因子：
4.3
作者：
Bijlsma, Lubertus;Beltran, Eduardo;Hernandez, Felix
通讯作者：
Hernandez, Felix
影响因子：
4.1
作者：
Bagnall, J. P.;Evans, S. E.;Kasprzyk-Hordern, B.
通讯作者：
Kasprzyk-Hordern, B.
DOI：
10.1111/j.1360-0443.2009.02678.x
发表时间：
2009-11
期刊：
Addiction (Abingdon, England)
影响因子：
--
作者：
Banta-Green CJ;Field JA;Chiaia AC;Sudakin DL;Power L;de Montigny L
通讯作者：
de Montigny L
影响因子：
8.8
作者：
Berset, Jean-Daniel;Brenneisen, Rudolf;Mathieu, Christoph
通讯作者：
Mathieu, Christoph