Rhythmic cortical neurons increase their oscillations and sculpt basal ganglia signaling during motor learning.
Rhythmic cortical neurons increase their oscillations and sculpt basal ganglia signaling during motor learning.
复制标题
DOI：
10.1002/dneu.22098
复制
发表时间：
2013-10
影响因子：
3
通讯作者：
Nick, Teresa A.
中科院分区：
文献类型：
--
作者：
Day, Nancy F.;Nick, Teresa A.
运动技能背后的神经回路的功能和调节可能涉及节律性振荡。在所提出的鸟鸣模式发生器中，皮层核 HVC、鸣叫期间振荡爆发的频率和功率随着发育而增加。我们检查了这些变化背后的细胞活动模式的成熟程度。采用单单元集合记录与逆向识别相结合的方法来研究麻醉斑胸草雀的网络发育。自协方差量化了单个单位内的振荡。一部分神经元在 theta/alpha/mu/beta 范围（8-20 Hz）内振荡，与青少年相比，成年人的能量更大。在整个网络中，成年人在 8-20 Hz 范围内的归一化振荡功率大于青少年。此外，节律性神经元对之间的相关活动随着发育而增加。接下来我们检查了振荡器对 HVC 输出神经元的功能影响。我们发现振荡神经元的放电与皮质基底神经节神经元 (HVCX) 的活动呈负相关，该神经元投射到 X 区（歌曲基底神经节）。如果振荡器组一起工作，以强直性抑制和精确控制成年 HVCX 的尖峰时间，并协调释放抑制，那么由于不相关的强直性抑制，青少年 HVCX 的活性相对于成人应该降低。与这一假设一致，HVCX 在青少年中的活性较低。这些数据揭示了运动学习过程中塑造皮质到基底神经节信号传导的网络变化。
The function and modulation of neural circuits underlying motor skill may involve rhythmic oscillations. In the proposed pattern generator for birdsong, the cortical nucleus HVC, the frequency and power of oscillatory bursting during singing increases with development. We examined the maturation of cellular activity patterns that underlie these changes. Single unit ensemble recording combined with antidromic identification was used to study network development in anesthetized zebra finches. Autocovariance quantified oscillations within single units. A subset of neurons oscillated in the theta/alpha/mu/beta range (8–20 Hz), with greater power in adults compared to juveniles. Across the network, the normalized oscillatory power in the 8–20 Hz range was greater in adults than juveniles. In addition, the correlated activity between rhythmic neuron pairs increased with development. We next examined the functional impact of the oscillators on the output neurons of HVC. We found that the firing of oscillatory neurons negatively correlated with the activity of cortico-basal ganglia neurons (HVCXs), which project to Area X (the song basal ganglia). If groups of oscillators work together to tonically inhibit and precisely control the spike timing of adult HVCXs with coordinated release from inhibition, then the activity of HVCXs in juveniles should be decreased relative to adults due to uncorrelated, tonic inhibition. Consistent with this hypothesis, HVCXs had lower activity in juveniles. These data reveal network changes that shape cortical-to-basal ganglia signaling during motor learning.
登录
查看更多内容
影响因子：
13.9
作者：
Buzsáki G;Wang XJ
通讯作者：
Wang XJ
影响因子：
4.7
作者：
Clarke, AR;Barry, RJ;Selikowitz, M
通讯作者：
Selikowitz, M
影响因子：
64.8
作者：
COBB, SR;BUHL, EH;SOMOGYI, P
通讯作者：
SOMOGYI, P
影响因子：
56.9
作者：
Dave, AS;Yu, AC;Margoliash, D
通讯作者：
Margoliash, D
影响因子：
56.9
作者：
Aronov, Dmitriy;Andalman, Aaron S.;Fee, Michale S.
通讯作者：
Fee, Michale S.