The decade of exosomal long RNA species: an emerging cancer antagonist.
The decade of exosomal long RNA species: an emerging cancer antagonist.
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外泌体长RNA物种的十年：一种新兴的癌症拮抗剂。
DOI：
10.1186/s12943-018-0823-z
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发表时间：
2018-03-20
期刊：
影响因子：
37.3
通讯作者：
Huang G
中科院分区：
文献类型：
--
作者：
Zhou R;Chen KK;Zhang J;Xiao B;Huang Z;Ju C;Sun J;Zhang F;Lv XB;Huang G
自2007年在外泌体中发现RNA含量后，外泌体已成为治疗和诊断癌症的一种新方法。作为细胞间通讯的重要介质，外泌体在过去十年中已成为研究人员研究的重点，外泌体研究的指数级增长就证明了这一点。外泌体转移功能活性货物的能力凸显了它们作为有前途的生物标志物和诊断分子以及前瞻性药物递送系统的重要性。由于外泌体对肿瘤形成和进展的广泛影响，几乎所有生物液中外泌体的可及性也暗示了其在各种类型的癌症中具有前所未有的能力。本综述分析了由 mRNA、lncRNA 和 circRNA 组成的外泌体长 RNA 在肿瘤形成和进展中的作用，重点介绍了它们作为癌症生物学中未来诊断生物标志物和治疗载体的潜力。鉴于过去十年中发表的外泌体研究的积累，本综述进一步研究了它们与外泌体数据库发展的一致性。
Exosomes have emerged as a novel approach for the treatment and diagnosis of cancer after RNA content was discovered in exosomes in 2007. As important meditators of intercellular communication, exosomes have become a strong focus of investigation for researchers in the past decade, as witnessed through the exponential increase of research on exosomes. The capability of exosomes to transfer functionally active cargo highlights their importance as promising biomarkers and diagnostic molecules, as well as prospective drug delivery systems. The accessibility of exosomes in nearly all biofluids additionally alludes to its unprecedented ability in various types of cancers due to its extensive impact on tumor formation and progression. This review analyzes the role of exosomal long RNA species, which is comprised of mRNA, lncRNA, and circRNA, in tumor formation and progression, with an emphasis on their potential as future diagnostic biomarkers and treatment vectors in cancer biology. Their alignment with the development of exosomal databases is further examined in this review, in view of the accumulation of studies published on exosomes in the past decade.
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作者：
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作者：
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